Literature DB >> 17160999

Anti-influenza virus agents: synthesis and mode of action.

Irene M Lagoja1, Erik De Clercq.   

Abstract

Annual epidemics of influenza virus infection are responsible for considerable morbidity and mortality, and pandemics are much more devastating. Considerable knowledge of viral infectivity and replication has been acquired, but many details still have to be elucidated and the virus remains a challenging target for drug design and development. This review provides an overview of the antiviral drugs targeting the influenza viral replicative cycle. Included are a brief description of their chemical syntheses and biological activities. For other reviews, see References1-9.

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Year:  2008        PMID： 17160999      PMCID： PMC7168508          DOI： 10.1002/med.20096

Source DB:  PubMed          Journal:  Med Res Rev        ISSN： 0198-6325            Impact factor:   12.944


  141 in total

1.  Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.

Authors:  W Lew; P A Escarpe; D B Mendel; D J Sweeny; C U Kim
Journal:  Bioorg Med Chem Lett       Date:  1999-10-04       Impact factor: 2.823

2.  Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells.

Authors:  Y Kawaoka; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

3.  Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones.

Authors:  D L Bodian; R B Yamasaki; R L Buswell; J F Stearns; J M White; I D Kuntz
Journal:  Biochemistry       Date:  1993-03-30       Impact factor: 3.162

4.  Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans.

Authors:  F G Hayden; A R Tunkel; J J Treanor; R F Betts; S Allerheiligen; J Harris
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191

5.  Basis for the potent inhibition of influenza virus infection by equine and guinea pig alpha 2-macroglobulin.

Authors:  T J Pritchett; J C Paulson
Journal:  J Biol Chem       Date:  1989-06-15       Impact factor: 5.157

6.  Resistance of mice to reinfection after E-aminocaproic acid treatment of primary influenza virus infection.

Authors:  V P Lozitsky; L E Puzis
Journal:  Acta Virol       Date:  1988-03       Impact factor: 1.162

7.  Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir.

Authors:  Takeshi Masuda; Satoshi Shibuya; Masami Arai; Shuku Yoshida; Takanori Tomozawa; Akiko Ohno; Makoto Yamashita; Takeshi Honda
Journal:  Bioorg Med Chem Lett       Date:  2003-02-24       Impact factor: 2.823

8.  Enantioselective synthesis of antiinfluenza compound A-315675.

Authors:  David A DeGoey; Hui-Ju Chen; William J Flosi; David J Grampovnik; Clinton M Yeung; Larry L Klein; Dale J Kempf
Journal:  J Org Chem       Date:  2002-08-09       Impact factor: 4.354

9.  Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives.

Authors:  Takeshi Masuda; Shuku Yoshida; Masami Arai; Satoru Kaneko; Makoto Yamashita; Takeshi Honda
Journal:  Chem Pharm Bull (Tokyo)       Date:  2003-12       Impact factor: 1.645

Review 10.  The molecular biology of influenza virus pathogenicity.

Authors:  H D Klenk; R Rott
Journal:  Adv Virus Res       Date:  1988       Impact factor: 9.937
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  28 in total

1.  Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.

Authors:  Jizhou Wang; Chunlong Ma; Jun Wang; Hyunil Jo; Belgin Canturk; Giacomo Fiorin; Lawrence H Pinto; Robert A Lamb; Michael L Klein; William F DeGrado
Journal:  J Med Chem       Date:  2013-03-27       Impact factor: 7.446

2.  Mutagenesis studies of the H5 influenza hemagglutinin stem loop region.

Authors:  Aleksandar Antanasijevic; Arnab Basu; Terry L Bowlin; Rama K Mishra; Lijun Rong; Michael Caffrey
Journal:  J Biol Chem       Date:  2014-06-19       Impact factor: 5.157

3.  Discovery and SAR study of piperidine-based derivatives as novel influenza virus inhibitors.

Authors:  Guoxin Wang; Longjian Chen; Tongmei Xian; Yujie Liang; Xintao Zhang; Zhen Yang; Ming Luo
Journal:  Org Biomol Chem       Date:  2014-10-28       Impact factor: 3.876

4.  Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

Authors:  Jun Wang; Chunlong Ma; Giacomo Fiorin; Vincenzo Carnevale; Tuo Wang; Fanghao Hu; Robert A Lamb; Lawrence H Pinto; Mei Hong; Michael L Klein; William F DeGrado
Journal:  J Am Chem Soc       Date:  2011-07-21       Impact factor: 15.419

5.  Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.

Authors:  Jun Wang; Chunlong Ma; Victoria Balannik; Lawrence H Pinto; Robert A Lamb; William F Degrado
Journal:  ACS Med Chem Lett       Date:  2011-04-14       Impact factor: 4.345

6.  Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.

Authors:  María D Duque; Chunlong Ma; Eva Torres; Jun Wang; Lieve Naesens; Jordi Juárez-Jiménez; Pelayo Camps; F Javier Luque; William F DeGrado; Robert A Lamb; Lawrence H Pinto; Santiago Vázquez
Journal:  J Med Chem       Date:  2011-04-05       Impact factor: 7.446

7.  Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.

Authors:  Mark N Prichard; Debra C Quenelle; Caroll B Hartline; Emma A Harden; Geraldine Jefferson; Samuel L Frederick; Shannon L Daily; Richard J Whitley; Kamal N Tiwari; Joseph A Maddry; John A Secrist; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

8.  Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus.

Authors:  Victoria Balannik; Jun Wang; Yuki Ohigashi; Xianghong Jing; Emma Magavern; Robert A Lamb; William F Degrado; Lawrence H Pinto
Journal:  Biochemistry       Date:  2009-12-22       Impact factor: 3.162

9.  Evidence for a novel gene associated with human influenza A viruses.

Authors:  Monica Clifford; James Twigg; Chris Upton
Journal:  Virol J       Date:  2009-11-16       Impact factor: 4.099

10.  Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.

Authors:  Jun Wang; Yibing Wu; Chunlong Ma; Giacomo Fiorin; Jizhou Wang; Lawrence H Pinto; Robert A Lamb; Michael L Klein; William F Degrado
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-09       Impact factor: 11.205
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