Literature DB >> 15006365

Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein.

Hang Yin1, Andrew D Hamilton.   

Abstract

A group of novel Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, were designed to mimic the alpha-helical region of the Bak peptide. Good in vitro inhibition potencies in disrupting the Bak/Bcl-xL complex have been observed (terephthalamide 4, K(i)=0.78+/-0.07 microM).

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Year:  2004        PMID： 15006365     DOI： 10.1016/j.bmcl.2003.09.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

Review 1.  Targeting protein-protein interactions for cancer therapy.

Authors:  David C Fry; Lyubomir T Vassilev
Journal:  J Mol Med (Berl)       Date:  2005-11-11       Impact factor: 4.599

Review 2.  Targeting protein-protein interactions by rational design: mimicry of protein surfaces.

Authors:  Steven Fletcher; Andrew D Hamilton
Journal:  J R Soc Interface       Date:  2006-04-22       Impact factor: 4.118

Review 3.  Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.

Authors:  Duncan E Scott; Andrew R Bayly; Chris Abell; John Skidmore
Journal:  Nat Rev Drug Discov       Date:  2016-04-11       Impact factor: 84.694

4.  Topomimetics of amphipathic beta-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins.

Authors:  Xuemei Chen; Ruud P M Dings; Irina Nesmelova; Stefan Debbert; Judith R Haseman; Jacques Maxwell; Thomas R Hoye; Kevin H Mayo
Journal:  J Med Chem       Date:  2006-12-28       Impact factor: 7.446

Review 5.  Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review.

Authors:  Naval Bajwa; Chenzhong Liao; Zaneta Nikolovska-Coleska
Journal:  Expert Opin Ther Pat       Date:  2011-12-23       Impact factor: 6.674

6.  Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

Authors:  Alex Shaginian; Landon R Whitby; Sukwon Hong; Inkyu Hwang; Bilal Farooqi; Mark Searcey; Jiandong Chen; Peter K Vogt; Dale L Boger
Journal:  J Am Chem Soc       Date:  2009-04-22       Impact factor: 15.419

7.  Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic.

Authors:  Sofia Caria; Srishti Chugh; Duong Nhu; Guillaume Lessene; Marc Kvansakul
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-11-14

Review 8.  Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

Authors:  Marta Pelay-Gimeno; Adrian Glas; Oliver Koch; Tom N Grossmann
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-26       Impact factor: 15.336

Review 9.  Multi-Facial, Non-Peptidic α-Helix Mimetics.

Authors:  Maryanna E Lanning; Steven Fletcher
Journal:  Biology (Basel)       Date:  2015-08-31
  9 in total

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