| Literature DB >> 15004103 |
Madalene Richardson1, Gian D van der Spuy, Samantha L Sampson, Nulda Beyers, Paul D van Helden, Robin M Warren.
Abstract
Mycobacterium tuberculosis cultures were subjected to DNA fingerprinting with IS6110- and polymorphic GC-rich sequence (PGRS)-containing probes. The PGRS banding patterns remained highly stable during multiple cultures of specimens from one disease episode (0.5% changed) and during transmission in patients with close contact (1.9% changed). Characteristic PGRS-restriction fragment length polymorphism motifs for different strain groupings may indicate distant evolutionary events leading to the differentiation of M. tuberculosis strain lineages.Entities:
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Year: 2004 PMID: 15004103 PMCID: PMC356821 DOI: 10.1128/JCM.42.3.1302-1304.2004
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948