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Literature DB >> 14993926

A topological view of the replicon.

Abstract

The replication of circular DNA faces topological obstacles that need to be overcome to allow the complete duplication and separation of newly replicated molecules. Small bacterial plasmids provide a perfect model system to study the interplay between DNA helicases, polymerases, topoisomerases and the overall architecture of partially replicated molecules. Recent studies have shown that partially replicated circular molecules have an amazing ability to form various types of structures (supercoils, precatenanes, knots and catenanes) that help to accommodate the dynamic interplay between duplex unwinding at the replication fork and DNA unlinking by topoisomerases.

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Year: 2004 PMID： 14993926 PMCID： PMC1299012 DOI： 10.1038/sj.embor.7400101

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

48 in total

Review 1. Knot what we thought before: the twisted story of replication.

Authors: L Postow; B J Peter; N R Cozzarelli
Journal: Bioessays Date: 1999-10 Impact factor: 4.345

2. Visualisation of plasmid replication intermediates containing reversed forks.

Authors: E Viguera; P Hernández; D B Krimer; R Lurz; J B Schvartzman
Journal: Nucleic Acids Res Date: 2000-01-15 Impact factor: 16.971

Review 3. Mechanisms of separation of the complementary strands of DNA during replication.

Authors: A I Alexandrov; N R Cozzarelli; V F Holmes; A B Khodursky; B J Peter; L Postow; V Rybenkov; A V Vologodskii
Journal: Genetica Date: 1999 Impact factor: 1.082

4. Premature termination of DNA replication in plasmids carrying two inversely oriented ColE1 origins.

Authors: D Santamaría; P Hernández; M L Martínez-Robles; D B Krimer; J B Schvartzman
Journal: J Mol Biol Date: 2000-06-30 Impact factor: 5.469

5. Formation of knots in partially replicated DNA molecules.

Authors: J M Sogo; A Stasiak; M L Martínez-Robles; D B Krimer; P Hernández; J B Schvartzman
Journal: J Mol Biol Date: 1999-02-26 Impact factor: 5.469

6. Positive torsional strain causes the formation of a four-way junction at replication forks.

Authors: L Postow; C Ullsperger; R W Keller; C Bustamante; A V Vologodskii; N R Cozzarelli
Journal: J Biol Chem Date: 2000-10-30 Impact factor: 5.157

7. Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays.

Authors: A B Khodursky; B J Peter; M B Schmid; J DeRisi; D Botstein; P O Brown; N R Cozzarelli
Journal: Proc Natl Acad Sci U S A Date: 2000-08-15 Impact factor: 11.205

8. Topoisomerase II can unlink replicating DNA by precatenane removal.

Authors: I Lucas; T Germe; M Chevrier-Miller; O Hyrien
Journal: EMBO J Date: 2001-11-15 Impact factor: 11.598

Review 9. Topological challenges to DNA replication: conformations at the fork.

Authors: L Postow; N J Crisona; B J Peter; C D Hardy; N R Cozzarelli
Journal: Proc Natl Acad Sci U S A Date: 2001-07-17 Impact factor: 11.205

10. Preferential relaxation of positively supercoiled DNA by E. coli topoisomerase IV in single-molecule and ensemble measurements.

Authors: N J Crisona; T R Strick; D Bensimon; V Croquette; N R Cozzarelli
Journal: Genes Dev Date: 2000-11-15 Impact factor: 11.361

62 in total

A topological view of the replicon.

Review 1. Knot what we thought before: the twisted story of replication.

2. Visualisation of plasmid replication intermediates containing reversed forks.

Review 3. Mechanisms of separation of the complementary strands of DNA during replication.

4. Premature termination of DNA replication in plasmids carrying two inversely oriented ColE1 origins.

5. Formation of knots in partially replicated DNA molecules.

6. Positive torsional strain causes the formation of a four-way junction at replication forks.

7. Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays.

8. Topoisomerase II can unlink replicating DNA by precatenane removal.

Review 9. Topological challenges to DNA replication: conformations at the fork.

10. Preferential relaxation of positively supercoiled DNA by E. coli topoisomerase IV in single-molecule and ensemble measurements.

1. Topological domain structure of the Escherichia coli chromosome.

2. Simulations of action of DNA topoisomerases to investigate boundaries and shapes of spaces of knots.

Review 3. Folded DNA in action: hairpin formation and biological functions in prokaryotes.

4. Braiding DNA: experiments, simulations, and models.

5. DNA packaging in bacteriophage: is twist important?

6. Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure.

7. The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.

8. Topological locking restrains replication fork reversal.

Review 9. SUMO modification of DNA topoisomerase II: trying to get a CENse of it all.

10. FtsK-dependent XerCD-dif recombination unlinks replication catenanes in a stepwise manner.