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Literature DB >> 14993420

LQT4 gene: the "missing" ankyrin.

Abstract

Mutations in ion channels have been implicated in the formation of long QT syndrome (LQTS). However, Mohler et al. have recently uncovered a role for ankyrin-B, a non-ion channel protein, in type IV LQTS. Calcium signalling is altered, and the functions of several channels and pumps that normally interact with wild-type ankyrin-B are impaired in the presence of mutant ankyrin-B. The authors suggest that by disrupting the functions of these channels, a new mechanism has been uncovered that can lead to cardiac myopathy.

Entities: Chemical Disease Gene

Mesh：

Substances：
Ankyrins

Year: 2003 PMID： 14993420 PMCID： PMC1618879 DOI： 10.1124/mi.3.3.131

Source DB: PubMed Journal: Mol Interv ISSN： 1534-0384

29 in total

1. Ibutilide and the treatment of atrial arrhythmias. A new drug--almost unheralded--is now available to US physicians.

Authors: D M Roden
Journal: Circulation Date: 1996-10-01 Impact factor: 29.690

Review 2. Genetics, molecular mechanisms and management of long QT syndrome.

Authors: Q Wang; Q Chen; J A Towbin
Journal: Ann Med Date: 1998-02 Impact factor: 4.709

3. KCNE1 mutations cause jervell and Lange-Nielsen syndrome.

Authors: E Schulze-Bahr; Q Wang; H Wedekind; W Haverkamp; Q Chen; Y Sun; C Rubie; M Hördt; J A Towbin; M Borggrefe; G Assmann; X Qu; J C Somberg; G Breithardt; C Oberti; H Funke
Journal: Nat Genet Date: 1997-11 Impact factor: 38.330

4. Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long-QT syndrome.

Authors: W Shimizu; T Kurita; K Matsuo; K Suyama; N Aihara; S Kamakura; J A Towbin; K Shimomura
Journal: Circulation Date: 1998-04-28 Impact factor: 29.690

5. Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome.

Authors: P Duggal; M R Vesely; D Wattanasirichaigoon; J Villafane; V Kaushik; A H Beggs
Journal: Circulation Date: 1998-01-20 Impact factor: 29.690

Review 6. The molecular genetics of the long QT syndrome: genes causing fainting and sudden death.

Authors: G M Vincent
Journal: Annu Rev Med Date: 1998 Impact factor: 13.739

7. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.

Authors: Q Wang; M E Curran; I Splawski; T C Burn; J M Millholland; T J VanRaay; J Shen; K W Timothy; G M Vincent; T de Jager; P J Schwartz; J A Toubin; A J Moss; D L Atkinson; G M Landes; T D Connors; M T Keating
Journal: Nat Genet Date: 1996-01 Impact factor: 38.330

8. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia.

Authors: Q Wang; J Shen; Z Li; K Timothy; G M Vincent; S G Priori; P J Schwartz; M T Keating
Journal: Hum Mol Genet Date: 1995-09 Impact factor: 6.150

9. Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium.

Authors: S J Compton; R L Lux; M R Ramsey; K R Strelich; M C Sanguinetti; L S Green; M T Keating; J W Mason
Journal: Circulation Date: 1996-09-01 Impact factor: 29.690

10. Mapping of a gene for long QT syndrome to chromosome 4q25-27.

Authors: J J Schott; F Charpentier; S Peltier; P Foley; E Drouin; J B Bouhour; P Donnelly; G Vergnaud; L Bachner; J P Moisan
Journal: Am J Hum Genet Date: 1995-11 Impact factor: 11.025

8 in total

Review 1. Slow delayed rectifier potassium current (IKs) and the repolarization reserve.

Authors: Norbert Jost; Julius Gy Papp; András Varró
Journal: Ann Noninvasive Electrocardiol Date: 2007-01 Impact factor: 1.468

2. Genome-wide linkage scan identifies a novel genetic locus on chromosome 5p13 for neonatal atrial fibrillation associated with sudden death and variable cardiomyopathy.

Authors: Carlos Oberti; Lejin Wang; Lin Li; Jiamei Dong; Shaoqi Rao; Wei Du; Qing Wang
Journal: Circulation Date: 2004-12-13 Impact factor: 29.690

LQT4 gene: the "missing" ankyrin.

1. Ibutilide and the treatment of atrial arrhythmias. A new drug--almost unheralded--is now available to US physicians.

Review 2. Genetics, molecular mechanisms and management of long QT syndrome.

3. KCNE1 mutations cause jervell and Lange-Nielsen syndrome.

4. Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long-QT syndrome.

5. Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome.

Review 6. The molecular genetics of the long QT syndrome: genes causing fainting and sudden death.

7. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.

8. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia.

9. Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium.

10. Mapping of a gene for long QT syndrome to chromosome 4q25-27.

Review 1. Slow delayed rectifier potassium current (IKs) and the repolarization reserve.

2. Genome-wide linkage scan identifies a novel genetic locus on chromosome 5p13 for neonatal atrial fibrillation associated with sudden death and variable cardiomyopathy.

Review 3. Molecular genetics of coronary artery disease.

4. Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.

5. Transcription factor MEF2A mutations in patients with coronary artery disease.

6. Long QT syndrome: from channels to cardiac arrhythmias.

Review 7. Congenital long-QT syndromes: a clinical and genetic update from infancy through adulthood.

Review 8. Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.