Literature DB >> 17286653

Slow delayed rectifier potassium current (IKs) and the repolarization reserve.

Norbert Jost1, Julius Gy Papp, András Varró.   

Abstract

The aim of this review is to present the properties of the slow component of the delayed rectifier potassium current (IKs) in the human ventricle. The review gives a detailed description of the physiology, molecular biology and pharmacology of the IKs current, including kinetic properties, genetic structures, agonists and antagonists. The authors also present the role of the IKs current in the human cardiac repolarization focusing on several pathophysiological situations, such as the LQT syndrome and the Torsade de Pointes arrhythmia.

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Year:  2007        PMID： 17286653      PMCID： PMC6931982          DOI： 10.1111/j.1542-474X.2007.00140.x

Source DB:  PubMed          Journal:  Ann Noninvasive Electrocardiol        ISSN： 1082-720X            Impact factor:   1.468


  93 in total

1.  KvLQT1 modulates the distribution and biophysical properties of HERG. A novel alpha-subunit interaction between delayed rectifier currents.

Authors:  Joachim R Ehrlich; Marc Pourrier; Manjula Weerapura; Nathalie Ethier; Aida M Marmabachi; Terence E Hébert; Stanley Nattel
Journal:  J Biol Chem       Date:  2003-10-29       Impact factor: 5.157

2.  Differential effect of beta-adrenergic stimulation on the frequency-dependent electrophysiologic actions of the new class III antiarrhythmics dofetilide, ambasilide, and chromanol 293B.

Authors:  J Schreieck; Y Wang; V Gjini; M Korth; B Zrenner; A Schömig; C Schmitt
Journal:  J Cardiovasc Electrophysiol       Date:  1997-12

3.  The role of the IsK protein in the specific pharmacological properties of the IKs channel complex.

Authors:  A E Busch; G L Busch; E Ford; H Suessbrich; H J Lang; R Greger; K Kunzelmann; B Attali; W Stühmer
Journal:  Br J Pharmacol       Date:  1997-09       Impact factor: 8.739

Review 4.  Role of the ISK protein in the IminK channel complex.

Authors:  A E Busch; H Suessbrich
Journal:  Trends Pharmacol Sci       Date:  1997-01       Impact factor: 14.819

5.  Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration.

Authors:  C Lengyel; N Iost; L Virág; A Varró; D A Lathrop; J G Papp
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

6.  Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles.

Authors:  Petsy Pui-Sze So; Xu-Dong Hu; Peter H Backx; José Luis Puglisi; Paul Dorian
Journal:  Br J Pharmacol       Date:  2006-06       Impact factor: 8.739

7.  Expression of a minimal K+ channel protein in mammalian cells and immunolocalization in guinea pig heart.

Authors:  L C Freeman; R S Kass
Journal:  Circ Res       Date:  1993-11       Impact factor: 17.367

8.  Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2.

Authors:  I Splawski; J Shen; K W Timothy; M H Lehmann; S Priori; J L Robinson; A J Moss; P J Schwartz; J A Towbin; G M Vincent; M T Keating
Journal:  Circulation       Date:  2000-09-05       Impact factor: 29.690

9.  Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks).

Authors:  Andrew L Lundquist; Lauren J Manderfield; Carlos G Vanoye; Christopher S Rogers; Brian S Donahue; Paul A Chang; Davis C Drinkwater; Katherine T Murray; Alfred L George
Journal:  J Mol Cell Cardiol       Date:  2005-01-20       Impact factor: 5.000

10.  Sotalol testing unmasks altered repolarization in patients with suspected acquired long-QT-syndrome--a case-control pilot study using i.v. sotalol.

Authors:  Stefan Kääb; Martin Hinterseer; Michael Näbauer; Gerhard Steinbeck
Journal:  Eur Heart J       Date:  2003-04       Impact factor: 29.983
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  29 in total

1.  Role of slow delayed rectifying potassium current in dynamics of repolarization and electrical memory in swine ventricles.

Authors:  Linyuan Jing; Kathleen Brownson; Abhijit Patwardhan
Journal:  J Physiol Sci       Date:  2014-03-30       Impact factor: 2.781

2.  Prenatal nicotinic exposure prolongs superior laryngeal C-fiber-mediated apnea and bradycardia through enhancing neuronal TRPV1 expression and excitation.

Authors:  Xiuping Gao; Lei Zhao; Jianguo Zhuang; Na Zang; Fadi Xu
Journal:  FASEB J       Date:  2017-06-14       Impact factor: 5.191

3.  Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation.

Authors:  Tao Yang; Hideaki Kanki; Wei Zhang; Dan M Roden
Journal:  Br J Pharmacol       Date:  2009-06-12       Impact factor: 8.739

4.  Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks).

Authors:  Daniel Werry; Jodene Eldstrom; Zhuren Wang; David Fedida
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-19       Impact factor: 11.205

Review 5.  Ion Channels in the Heart.

Authors:  Daniel C Bartos; Eleonora Grandi; Crystal M Ripplinger
Journal:  Compr Physiol       Date:  2015-07-01       Impact factor: 9.090

6.  Contribution of potassium channels to action potential repolarization of human embryonic stem cell-derived cardiomyocytes.

Authors:  Yin Wang; Renjun Zhu; Leslie Tung
Journal:  Br J Pharmacol       Date:  2019-06-26       Impact factor: 8.739

7.  Size matters, proportion too: coupling of experiments and theory reveals relative roles of K+ channels in action potential stability.

Authors:  Eleonora Grandi
Journal:  J Physiol       Date:  2017-01-11       Impact factor: 5.182

8.  A novel computational model of the human ventricular action potential and Ca transient.

Authors:  Eleonora Grandi; Francesco S Pasqualini; Donald M Bers
Journal:  J Mol Cell Cardiol       Date:  2009-10-14       Impact factor: 5.000

9.  Rabbit ventricular myocardium undergoing simulated ischemia and reperfusion in a double compartment tissue bath: a model to investigate both antiarrhythmic and arrhythmogenic likelihood.

Authors:  Joachim Alexandre; Michele Schiariti; René Rouet; Paolo Emilio Puddu
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2013-03-08

10.  Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks).

Authors:  Joffrey Ducroq; H Moha ou Maati; S Guilbot; S Dilly; E Laemmel; C Pons-Himbert; J F Faivre; P Bois; O Stücker; M Le Grand
Journal:  Br J Pharmacol       Date:  2009-08-24       Impact factor: 8.739
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