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Literature DB >> 19185812

Congenital long-QT syndromes: a clinical and genetic update from infancy through adulthood.

Abstract

Long-QT syndromes (LQTSs) have been described in all ages and are a significant cause of cardiovascular mortality, especially in structurally normal hearts. Abnormalities in transmembrane ion conduction channels and structural proteins produce these clinical syndromes, labeled LQT1-LQT12; however, genotype-positive patients still represent only about 70% of LQTSs. Future research will determine the etiology of the remaining cases, further risk-stratify the known genetic defects, improve current treatment options for these syndromes, and uncover novel therapies.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2008 PMID： 19185812 PMCID： PMC4260467 DOI： 10.1016/j.tcm.2008.11.002

Source DB: PubMed Journal: Trends Cardiovasc Med ISSN： 1050-1738 Impact factor: 6.677

57 in total

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Journal: Circulation Date: 2001-01-02 Impact factor: 29.690

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Journal: Circulation Date: 1998-06-09 Impact factor: 29.690

9 in total

1. Azithromycin Causes a Novel Proarrhythmic Syndrome.

Authors: Zhenjiang Yang; Joseph K Prinsen; Kevin R Bersell; Wangzhen Shen; Liudmila Yermalitskaya; Tatiana Sidorova; Paula B Luis; Lynn Hall; Wei Zhang; Liping Du; Ginger Milne; Patrick Tucker; Alfred L George; Courtney M Campbell; Robert A Pickett; Christian M Shaffer; Nagesh Chopra; Tao Yang; Bjorn C Knollmann; Dan M Roden; Katherine T Murray
Journal: Circ Arrhythm Electrophysiol Date: 2017-04

2. Cardiomyocyte calcium cycling in a naturally occurring German shepherd dog model of inherited ventricular arrhythmia and sudden cardiac death.

Authors: Sophy A Jesty; Seung Woo Jung; Jonathan M Cordeiro; Teresa M Gunn; José M Di Diego; Shari Hemsley; Bruce G Kornreich; Giles Hooker; Charles Antzelevitch; N Sydney Moïse
Journal: J Vet Cardiol Date: 2013-02-20 Impact factor: 1.701

Review 3. Pathogenesis and management of Brugada syndrome.

Authors: Juan Sieira; Gregory Dendramis; Pedro Brugada
Journal: Nat Rev Cardiol Date: 2016-09-15 Impact factor: 32.419

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Authors: Dong-fang Gu; Xue-lian Li; Zhi-ping Qi; Sha-shan Shi; Mei-qin Hu; Dong-min Liu; Cheng-bai She; Yan-jie Lv; Bao-xin Li; Bao-feng Yang
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2009-05-08 Impact factor: 3.000

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Authors: Ohad Ziv; Eduardo Morales; Yoon-kyu Song; Xuwen Peng; Katja E Odening; Alfred E Buxton; Alain Karma; Gideon Koren; Bum-Rak Choi
Journal: J Physiol Date: 2009-08-12 Impact factor: 5.182

9. QTc prolongation prior to angiography predicts poor outcome and associates significantly with lower left ventricular ejection fractions and higher left ventricular end-diastolic pressures.

Authors: P van der Bijl; M Heradien; A Doubell; P Brink
Journal: Cardiovasc J Afr Date: 2012-11 Impact factor: 1.167