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Literature DB >> 14992287

Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons.

Claus F Poulsen¹, Timothy A Simeone, Thomas E Maar, Virginia Smith-Swintosky, H Steven White, Arne Schousboe.

Abstract

The effect of the antiepileptic drug topiramate on Ca2+ uptake through (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate (AMPA) and kainate (KA) receptors was investigated in different cell culture systems consisting of neurons from the cerebral cortex, hippocampus, and cerebellum. Ca2+ influx was assayed using a fluorescent Ca2+ chelator to monitor changes in the intracellular Ca2+ concentration or cobalt staining to assess the effect of topiramate on Ca2+-permeable AMPA/KA receptors. In all types of neuronal cultures studied, AMPA and KA were found to elicit an influx of Ca2+ in a subset of the neuronal population. Topiramate, at concentrations of 30 and 100 microM, inhibited Ca2+ influx by up to 60%. Modulation of AMPA and KA-evoked Ca2+ influx may contribute to both the antiepileptic and neuroprotective properties of topiramate.

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 14992287 DOI： 10.1023/b:nere.0000010456.92887.3b

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

35 in total

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