S Bölte1, F Poustka. 1. Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters des Klinikums der Johann Wolfgang Goethe-Universität Frankfurt am Mair. Boelte@em.uni-frankfurt.de
Abstract
OBJECTIVE: To examine the psychometric properties of the German version of the Autism Diagnostic Observation Schedule (ADOS). METHODS: Interrater and retest reliability, internal consistency, convergent and diagnostic validity were determined in a total sample of 137 subjects with autism, 23 with atypical autism or pervasive developmental disorder not otherwise specified, 16 with Asperger-syndrome and 13 with other psychiatric disorders. RESULTS: Interrater and retest reliability on the level of diagnosis (kappa w = 1.00 and .62) and raw-scores (ru = .84 and .79) were good. Likewise, the internal consistency of the algorithm scale communication and social interaction of modules 1 to 4 was fair (ru = .78 to .89). The categorical convergence for autism between the ADOS and the Autism Diagnostic Interview-Revised (ADI-R) reached 79% (kappa = .23), with their corresponding subscales correlating moderately (rtc = .31 to .45). The concordance of the ADOS judgment and the clinical consensus diagnosis was 77% (kappa w = .37), with a sensitivity of the ADOS of 90.4% and a specificity of 48.1% regarding the discrimination of autism and other autistic disorders. CONCLUSIONS: The ADOS is a reliable and sufficiently sensitive diagnostic tool in the assessment of autistic disorders. For ICD-10/DSM-IV classification and to ensure a high specificity of diagnosis additional information concerning repetitive, stereotyped behavior and early development (e.g. taken from the ADI-R) has to be collected.
OBJECTIVE: To examine the psychometric properties of the German version of the Autism Diagnostic Observation Schedule (ADOS). METHODS: Interrater and retest reliability, internal consistency, convergent and diagnostic validity were determined in a total sample of 137 subjects with autism, 23 with atypical autism or pervasive developmental disorder not otherwise specified, 16 with Asperger-syndrome and 13 with other psychiatric disorders. RESULTS: Interrater and retest reliability on the level of diagnosis (kappa w = 1.00 and .62) and raw-scores (ru = .84 and .79) were good. Likewise, the internal consistency of the algorithm scale communication and social interaction of modules 1 to 4 was fair (ru = .78 to .89). The categorical convergence for autism between the ADOS and the Autism Diagnostic Interview-Revised (ADI-R) reached 79% (kappa = .23), with their corresponding subscales correlating moderately (rtc = .31 to .45). The concordance of the ADOS judgment and the clinical consensus diagnosis was 77% (kappa w = .37), with a sensitivity of the ADOS of 90.4% and a specificity of 48.1% regarding the discrimination of autism and other autistic disorders. CONCLUSIONS: The ADOS is a reliable and sufficiently sensitive diagnostic tool in the assessment of autistic disorders. For ICD-10/DSM-IV classification and to ensure a high specificity of diagnosis additional information concerning repetitive, stereotyped behavior and early development (e.g. taken from the ADI-R) has to be collected.
Authors: Christine M Freitag; Konstantin Agelopoulos; Ellen Huy; Matthias Rothermundt; Petra Krakowitzky; Jobst Meyer; Jürgen Deckert; Alexander von Gontard; Christa Hohoff Journal: Eur Child Adolesc Psychiatry Date: 2009-06-30 Impact factor: 4.785
Authors: Andreas G Chiocchetti; Afsheen Yousaf; Hannah S Bour; Denise Haslinger; Regina Waltes; Eftichia Duketis; Tomas Jarczok; Michael Sachse; Monica Biscaldi; Franziska Degenhardt; Stefan Herms; Sven Cichon; Jörg Ackermann; Ina Koch; Sabine M Klauck; Christine M Freitag Journal: J Neural Transm (Vienna) Date: 2017-11-16 Impact factor: 3.575
Authors: Regina Waltes; Eftichia Duketis; Michael Knapp; Richard J L Anney; Guillaume Huguet; Sabine Schlitt; Tomasz A Jarczok; Michael Sachse; Laura M Kämpfer; Tina Kleinböck; Fritz Poustka; Sven Bölte; Gabriele Schmötzer; Anette Voran; Ellen Huy; Jobst Meyer; Thomas Bourgeron; Sabine M Klauck; Christine M Freitag; Andreas G Chiocchetti Journal: Hum Genet Date: 2014-01-19 Impact factor: 4.132