Literature DB >> 14983060

Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission.

Crystal C Watkins1, Darren Boehning, Adam I Kaplin, Mahil Rao, Christopher D Ferris, Solomon H Snyder.   

Abstract

Carbon monoxide (CO) synthesized by heme oxygenase 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncholinergic (NANC) intestinal relaxation. In many areas of the gastrointestinal tract, NO and CO function as coneurotransmitters. In the internal anal sphincter (IAS), NANC relaxation is mediated primarily by CO. Vasoactive intestinal polypeptide (VIP) has also been shown to participate in NANC relaxation throughout the intestine, including the IAS. By using a combination of pharmacology and genetic knockout of the biosynthetic enzymes for CO and NO, we show that the physiologic effects of exogenous and endogenous VIP in the IAS are mediated by HO2-synthesized CO.

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Year:  2004        PMID： 14983060      PMCID： PMC357001          DOI： 10.1073/pnas.0308695100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  41 in total

1.  Heme oxygenase activity in the internal anal sphincter: effects of nonadrenergic, noncholinergic nerve stimulation.

Authors:  S Chakder; G Y Cao; R B Lynn; S Rattan
Journal:  Gastroenterology       Date:  2000-03       Impact factor: 22.682

2.  Characterization of an immunofluorescence technique for the demonstration of coexisting neurotransmitters within nerve fibers and terminals.

Authors:  M W Wessendorf; R P Elde
Journal:  J Histochem Cytochem       Date:  1985-10       Impact factor: 2.479

3.  Vasoactive intestinal polypeptide as possible mediator of relaxation in the rat gastric fundus.

Authors:  F A De Beurme; R A Lefebvre
Journal:  J Pharm Pharmacol       Date:  1988-10       Impact factor: 3.765

4.  A fragment of vasoactive intestinal peptide, VIP(10-28), is an antagonist of VIP in the colon carcinoma cell line, HT29.

Authors:  J T Turner; S B Jones; D B Bylund
Journal:  Peptides       Date:  1986 Sep-Oct       Impact factor: 3.750

5.  Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase.

Authors:  R Battish; G Y Cao; R B Lynn; S Chakder; S Rattan
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2000-01       Impact factor: 4.052

6.  A mammalian iron ATPase induced by iron.

Authors:  D E Barañano; H Wolosker; B I Bae; R K Barrow; S H Snyder; C D Ferris
Journal:  J Biol Chem       Date:  2000-05-19       Impact factor: 5.157

7.  Role of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum.

Authors:  S Nurko; S Rattan
Journal:  J Clin Invest       Date:  1988-04       Impact factor: 14.808

8.  Haem oxygenase-1 prevents cell death by regulating cellular iron.

Authors:  C D Ferris; S R Jaffrey; A Sawa; M Takahashi; S D Brady; R K Barrow; S A Tysoe; H Wolosker; D E Barañano; S Doré; K D Poss; S H Snyder
Journal:  Nat Cell Biol       Date:  1999-07       Impact factor: 28.824

9.  Influence of heme oxygenase inhibitors on the basal tissue enzymatic activity and smooth muscle relaxation of internal anal sphincter.

Authors:  S Rattan; S Chakder
Journal:  J Pharmacol Exp Ther       Date:  2000-09       Impact factor: 4.030

10.  Peptidergic (VIP) innervation of the esophagus.

Authors:  R Uddman; J Alumets; L Edvinsson; R Håkanson; F Sundler
Journal:  Gastroenterology       Date:  1978-07       Impact factor: 22.682
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  7 in total

Review 1.  Use of carbon monoxide in minimizing ischemia/reperfusion injury in transplantation.

Authors:  Kikumi S Ozaki; Shoko Kimura; Noriko Murase
Journal:  Transplant Rev (Orlando)       Date:  2011-10-13       Impact factor: 3.943

2.  Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization.

Authors:  Savita K Sharma; Hyun Kim; Patrick J Rogler; Maxime A Siegler; Kenneth D Karlin
Journal:  J Biol Inorg Chem       Date:  2016-06-27       Impact factor: 3.358

Review 3.  What Can Be Learned from Nuclear Resonance Vibrational Spectroscopy: Vibrational Dynamics and Hemes.

Authors:  W Robert Scheidt; Jianfeng Li; J Timothy Sage
Journal:  Chem Rev       Date:  2017-09-18       Impact factor: 60.622

4.  Evidence for an apamin-sensitive, but not purinergic, component in the nonadrenergic noncholinergic relaxation of the rat gastric fundus.

Authors:  Diego Currò; Teresina De Marco; Paolo Preziosi
Journal:  Br J Pharmacol       Date:  2004-10-25       Impact factor: 8.739

Review 5.  Parallel evolution of nitric oxide signaling: diversity of synthesis and memory pathways.

Authors:  Leonid L Moroz; Andrea B Kohn
Journal:  Front Biosci (Landmark Ed)       Date:  2011-06-01

Review 6.  Regulation of basal tone, relaxation and contraction of the lower oesophageal sphincter. Relevance to drug discovery for oesophageal disorders.

Authors:  R Farré; D Sifrim
Journal:  Br J Pharmacol       Date:  2007-11-12       Impact factor: 8.739

Review 7.  Hydrogen sulfide as a gasotransmitter.

Authors:  Moataz M Gadalla; Solomon H Snyder
Journal:  J Neurochem       Date:  2010-01-12       Impact factor: 5.372
  7 in total

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