Literature DB >> 401096

Peptidergic (VIP) innervation of the esophagus.

R Uddman1, J Alumets, L Edvinsson, R Håkanson, F Sundler.   

Abstract

Nerves displaying vasoactive intestinal polypeptide (VIP) immunoreactivity were demonstrated in the esophagus of rats, cats, and pigs. Furthermore, electron microscopy revealed the presence of nerve terminals displaying the features of peptidergic nerves. VIP nerves were abundant within the smooth muscle layer of the lower esophagus of cat and pig. Immunoreactive nerve fibers and nerve cell bodies were found in the plexuses of the esophageal wall. In pig fetuses VIP immunoreactive nerve cell bodies were observed already at crown-rump length of 4 cm. VIP nerves were also observed in human fetal esophagus. For recording of the motor effects of VIP, segments were taken from cat esophagus close to the esophagogastric junction. VIP induced a dose-dependent relaxation upon contraction by carbamylcholine.

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Year:  1978        PMID： 401096

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  23 in total

1.  Effects of vasoactive intestinal polypeptide (VIP) on lower esophageal sphincter in awake baboons: comparison with glucagon and secretin.

Authors:  S R Siegel; F C Brown; D O Castell; L F Johnson; S I Said
Journal:  Dig Dis Sci       Date:  1979-05       Impact factor: 3.199

2.  Studies of the guinea-pig epididymis. III. Innervation of epididymal segments.

Authors:  J Greenberg; W Schubert; J Metz; N Yanaihara; W G Forssmann
Journal:  Cell Tissue Res       Date:  1985       Impact factor: 5.249

3.  Intramural distribution of immunoreactive vasoactive intestinal polypeptide (VIP), substance P, somatostatin and mammalian bombesin in the oesophago-gastro-pyloric region of the human gut.

Authors:  G L Ferri; T E Adrian; L Soimero; M Blank; D Cavalli; G Biliotti; J M Polak; S R Bloom
Journal:  Cell Tissue Res       Date:  1989-04       Impact factor: 5.249

4.  Severe destruction of esophageal nerves in a patient with achalasia secondary to gastric cancer. A possible role of eosinophil neurotoxic proteins.

Authors:  K Fredens; A Tøttrup; I B Kristensen; R Dahl; N O Jacobsen; P Funch-Jensen; P Thommesen
Journal:  Dig Dis Sci       Date:  1989-02       Impact factor: 3.199

5.  Origin and development of VIP and substance P containing neurons in the embryonic avian gut.

Authors:  J Fontaine-Perus; M Chanconie; J M Polak; N M Le Douarin
Journal:  Histochemistry       Date:  1981

6.  Immunocytochemical localization of substance P, methionine-enkephalin and somatostatin in the cat intestinal wall.

Authors:  I Lolova; D Itzev; M Davidoff
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575

7.  Three-dimensional distribution of vasoactive intestinal polypeptide-containing structures in the rat stomach and their origins using whole mount tissue.

Authors:  H Inoue; S Shiosaka; Y Sasaki; N Hayashi; N Satoh; T Kamata; M Tohyama; Y Shiotani
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575

Review 8.  What's new in the esophagus.

Authors:  J Dent
Journal:  Dig Dis Sci       Date:  1981-02       Impact factor: 3.199

9.  Vasoactive intestinal polypeptide immunoreactivity in the spinal cord of the guinea pig. A mapping study.

Authors:  J Triepel; J Metz; D Munroe; S London; S Sweriduk; W G Forssmann
Journal:  Cell Tissue Res       Date:  1987-07       Impact factor: 5.249

10.  Vasoactive intestinal polypeptide. A neurotransmitter for lower esophageal sphincter relaxation.

Authors:  P Biancani; J H Walsh; J Behar
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808
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