Literature DB >> 19814623

The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.

Robert A Brown1, Jonathon H Gralewski, Raymund R Razonable.   

Abstract

Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.

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Year:  2009        PMID： 19814623      PMCID： PMC2761976          DOI： 10.1086/644501

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  15 in total

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