Literature DB >> 14977995

Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock.

Toshio Toyosawa1, Mamoru Suzuki, Kohtarou Kodama, Seiichi Araki.   

Abstract

Highly purified vitamin B2 (riboflavin 5'-sodium phosphate; purity > 97%) treatment by intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed therapeutic effects in mice not only in cases of endotoxin- and exotoxin-induced shock but also in cases of gram-negative and gram-positive bacterial infection even after the toxemia had already begun.

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Year:  2004        PMID： 14977995      PMCID： PMC356010          DOI： 10.1128/IAI.72.3.1820-1823.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


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