Literature DB >> 1487251

The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene.

M Gessler1, A Grupe, K H Grzeschik, O Pongs.   

Abstract

Transiently activating (A-type) potassium (K) channels are important regulators of action potential and action potential firing frequencies. HK1 designates the first human cDNA that is highly homologous to the rat RCK4 cDNA that codes for an A-type K-channel. The HK1 channel is expressed in heart. By somatic cell hybrid analysis, the HK1 gene has been assigned to human chromosome 11p13-p14, the WAGR deletion region (Wilms tumor, aniridia, genito-urinary abnormalities and mental retardation). Subsequent pulsed field gel (PFG) analysis and comparison with the well-established PFG map of this region localized the gene to 11p14,200-600 kb telomeric to the FSHB gene.

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Year:  1992        PMID： 1487251     DOI： 10.1007/bf00220091

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  15 in total

1.  Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle.

Authors:  M M Tamkun; K M Knoth; J A Walbridge; H Kroemer; D M Roden; D M Glover
Journal:  FASEB J       Date:  1991-03-01       Impact factor: 5.191

2.  A deletion map of the WAGR region on chromosome 11.

Authors:  M Gessler; G H Thomas; P Couillin; C Junien; B C McGillivray; M Hayden; G Jaschek; G A Bruns
Journal:  Am J Hum Genet       Date:  1989-04       Impact factor: 11.025

3.  Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region.

Authors:  C C Ton; H Hirvonen; H Miwa; M M Weil; P Monaghan; T Jordan; V van Heyningen; N D Hastie; H Meijers-Heijboer; M Drechsler
Journal:  Cell       Date:  1991-12-20       Impact factor: 41.582

4.  "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1984-02       Impact factor: 3.365

5.  Early outward current in rat single ventricular cells.

Authors:  I R Josephson; J Sanchez-Chapula; A M Brown
Journal:  Circ Res       Date:  1984-02       Impact factor: 17.367

6.  Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.

Authors:  K M Call; T Glaser; C Y Ito; A J Buckler; J Pelletier; D A Haber; E A Rose; A Kral; H Yeger; W H Lewis
Journal:  Cell       Date:  1990-02-09       Impact factor: 41.582

7.  DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11.

Authors:  P C Watkins; R Eddy; A K Beck; V Vellucci; B Leverone; R E Tanzi; J F Gusella; T B Shows
Journal:  DNA       Date:  1987-06

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes.

Authors:  K Willecke; S Jungbluth; E Dahl; H Hennemann; R Heynkes; K H Grzeschik
Journal:  Eur J Cell Biol       Date:  1990-12       Impact factor: 4.492

10.  Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

Authors:  W Stühmer; J P Ruppersberg; K H Schröter; B Sakmann; M Stocker; K P Giese; A Perschke; A Baumann; O Pongs
Journal:  EMBO J       Date:  1989-11       Impact factor: 11.598
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