Literature DB >> 148487

T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.

P J Wettstein, D W Bailey, L E Mobraaten, J Klein, J A Frelinger.   

Abstract

We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.

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Year:  1978        PMID： 148487      PMCID： PMC2184279          DOI： 10.1084/jem.147.5.1395

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  22 in total

1.  Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera.

Authors:  J E Niederhuber; J A Frelinger; E Dugan; A Coutinho; D C Shreffler
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  Immunogeneic analysis of H-2 mutations. II. Cellular immunity to the H-2DA mutation.

Authors:  J Forman; J Klein
Journal:  J Immunol       Date:  1975-09       Impact factor: 5.422

3.  Mixed lymphocyte reaction caused by an H-2D mutation (congenic strains-B10.D2 new-B10.504).

Authors:  M Rychlíková; P Démant; I K Egorov
Journal:  Folia Biol (Praha)       Date:  1972       Impact factor: 0.906

4.  Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: evidence for T cell interactions.

Authors:  O Stutman; F W Shen; E A Boyse
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

5.  Ly-4.2: a cell membrane alloantigen of murine B lymphocytes. I. Population studies.

Authors:  I F McKenzie; G D Snell
Journal:  J Immunol       Date:  1975-02       Impact factor: 5.422

6.  Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

Authors:  H Cantor; E A Boyse
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

7.  H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. II. H-2D region control of H-7.1-specific stimulator function in mixed lymphocyte culture and susceptibility to lysis by H-7.1-specific cytotoxic cells.

Authors:  P J Wettstein; J A Frelinger
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

8.  Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

Authors:  H Cantor; E A Boyse
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

9.  Cell-mediated lympholysis. Importance of serologically defined H-2 regions.

Authors:  B J Alter; D J Schendel; M L Bach; F H Bach; J Klein; J H Stimpfling
Journal:  J Exp Med       Date:  1973-05-01       Impact factor: 14.307

10.  Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.

Authors:  J Jandinski; H Cantor; T Tadakuma; D L Peavy; C W Pierce
Journal:  J Exp Med       Date:  1976-06-01       Impact factor: 14.307
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  11 in total

1.  T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.

Authors:  P J Wettstein; D W Bailey; L E Mobraaten; J Klein; J A Frelinger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

Review 2.  T cell subsets participating in the generation of cytotoxic T cells.

Authors:  M M Simon; K Eichmann
Journal:  Springer Semin Immunopathol       Date:  1980-05

3.  Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis.

Authors:  F Albert; M Buferne; C Boyer; A M Schmitt-Verhulst
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

4.  T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules.

Authors:  C Cowing; J M Chapdelaine
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

5.  Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products.

Authors:  A Rao; W J Allard; P G Hogan; R S Rosenson; H Cantor
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

6.  Interaction between MHC-encoded products and cloned T cells. II. Analyses of physiological requirements indicate two different pathways of stimulation by class I alloantigens.

Authors:  F Albert; C Boyer; M Buferne; A M Schmitt-Verhulst
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

7.  Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

Authors:  S L Swain
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

8.  Alternative pathways of T lymphocyte activation.

Authors:  F H Bach; B J Alter
Journal:  J Exp Med       Date:  1978-09-01       Impact factor: 14.307

9.  Enhancement of T lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations.

Authors:  E L Morgan; M L Thoman; W O Weigle
Journal:  J Exp Med       Date:  1981-05-01       Impact factor: 14.307

10.  Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens.

Authors:  T Mizuochi; S Ono; T R Malek; A Singer
Journal:  J Exp Med       Date:  1986-03-01       Impact factor: 14.307
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