| Literature DB >> 4267208 |
B J Alter, D J Schendel, M L Bach, F H Bach, J Klein, J H Stimpfling.
Abstract
The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2.Entities:
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Year: 1973 PMID： 4267208 PMCID： PMC2139243 DOI： 10.1084/jem.137.5.1303
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307