Literature DB >> 158760

T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.

P J Wettstein, D W Bailey, L E Mobraaten, J Klein, J A Frelinger.   

Abstract

The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kba and H-2Dda alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+ T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells.

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Year:  1979        PMID： 158760      PMCID： PMC383844          DOI： 10.1073/pnas.76.7.3455

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera.

Authors:  J E Niederhuber; J A Frelinger; E Dugan; A Coutinho; D C Shreffler
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  Immunogeneic analysis of H-2 mutations. II. Cellular immunity to the H-2DA mutation.

Authors:  J Forman; J Klein
Journal:  J Immunol       Date:  1975-09       Impact factor: 5.422

3.  Cell mediated lympholysis: CML. a microplate technique requiring few target cells and employing a new method of supernatant collection.

Authors:  H Hirschberg; H Skare; E Thorsby
Journal:  J Immunol Methods       Date:  1977       Impact factor: 2.303

4.  Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse.

Authors:  P Kisielow; J A Hirst; H Shiku; P C Beverley; M K Hoffman; E A Boyse; H F Oettgen
Journal:  Nature       Date:  1975-01-17       Impact factor: 49.962

5.  Lymphocytes as models for the study of mammalian cellular differentiation.

Authors:  H Cantor; E A Boyse
Journal:  Immunol Rev       Date:  1977-01       Impact factor: 12.988

6.  Structural differences between parent and variant H-2K glycoproteins from mouse strains carrying H-2 gene mutations.

Authors:  S G Nathenson; J L Brown; B M Ewenstein; T Nisizawa; D W Sears; J H Freed
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

7.  Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: evidence for T cell interactions.

Authors:  O Stutman; F W Shen; E A Boyse
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  An Lyt differentiated thymocyte subpopulation detected by flow microfluorometry.

Authors:  B J Mathieson; S O Sharrow; P S Campbell; R Asofsky
Journal:  Nature       Date:  1979-02-08       Impact factor: 49.962

9.  Alternative pathways of T lymphocyte activation.

Authors:  F H Bach; B J Alter
Journal:  J Exp Med       Date:  1978-09-01       Impact factor: 14.307

10.  T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.

Authors:  P J Wettstein; D W Bailey; L E Mobraaten; J Klein; J A Frelinger
Journal:  J Exp Med       Date:  1978-05-01       Impact factor: 14.307
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  18 in total

1.  Immunodominance in the T-cell response to multiple non-H-2 histocompatibility antigens. II. Observation of a hierarchy among dominant antigens.

Authors:  P J Wettstein
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue.

Authors:  N D Borson; C Paul; X Lin; W K Nevala; M A Strausbauch; M Rodriguez; P J Wettstein
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

3.  A new murine lymphocyte alloantigen, Ly-27.2.

Authors:  G K Matsushima; R C Harmon; J A Frelinger
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

Review 4.  T cell subsets participating in the generation of cytotoxic T cells.

Authors:  M M Simon; K Eichmann
Journal:  Springer Semin Immunopathol       Date:  1980-05

5.  Histocompatibility antigen changes associated with pink-eyed dilute (p) mutations.

Authors:  P J Wettstein; V Chapman; E Birkenmeier
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

6.  Alloreactive cytotoxic T lymphocyte responses to H-2 products on purified accessory cells.

Authors:  A A Czitrom; D R Katz; G H Sunshine
Journal:  Immunology       Date:  1982-03       Impact factor: 7.397

7.  Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products.

Authors:  A Rao; W J Allard; P G Hogan; R S Rosenson; H Cantor
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

8.  Immunodominance in the immune response to "multiple" histocompatibility antigens.

Authors:  P J Wettstein; D W Bailey
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

Review 9.  Natural and induced immunity to mouse mammary tumors and the mammary tumor virus (MuMTV).

Authors:  O Stutman
Journal:  Springer Semin Immunopathol       Date:  1982

10.  Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigens.

Authors:  C D Platsoucas; R A Good
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205
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