Literature DB >> 14749784

Age-related changes in lymphocyte development and function.

Phyllis Jean Linton1, Kenneth Dorshkind.   

Abstract

The effects of aging on the immune system are widespread and extend from hematopoietic stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes in secondary lymphoid organs. These changes combine to result in a diminution of immune responsiveness in the elderly. This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research.

Mesh：

Year:  2004        PMID： 14749784     DOI： 10.1038/ni1033

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  426 in total

1.  Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.

Authors:  Adrian J Reber; Tatiana Chirkova; Jin Hyang Kim; Weiping Cao; Renata Biber; David K Shay; Suryaprakash Sambhara
Journal:  Aging Dis       Date:  2011-09-30       Impact factor: 6.745

2.  Finding Balance: T cell Regulatory Receptor Expression during Aging.

Authors:  Mary M Cavanagh; Qian Qi; Cornelia M Weyand; Jörg J Goronzy
Journal:  Aging Dis       Date:  2011-10-28       Impact factor: 6.745

3.  The origin and implication of thymic involution.

Authors:  Danielle Aw; Donald B Palmer
Journal:  Aging Dis       Date:  2011-10-28       Impact factor: 6.745

4.  Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma.

Authors:  Jingang Gui; Lisa Maria Mustachio; Dong-Ming Su; Ruth W Craig
Journal:  Aging Dis       Date:  2012-03-14       Impact factor: 6.745

5.  Age-related deregulation of naive T cell homeostasis in elderly humans.

Authors:  Sara Ferrando-Martínez; Ezequiel Ruiz-Mateos; Ana Hernández; Encarnación Gutiérrez; Maria del Mar Rodríguez-Méndez; Antonio Ordoñez; Manuel Leal
Journal:  Age (Dordr)       Date:  2010-08-11

6.  Early immune senescence in HIV disease.

Authors:  Seema Desai; Alan Landay
Journal:  Curr HIV/AIDS Rep       Date:  2010-02       Impact factor: 5.071

7.  c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.

Authors:  Chozhavendan Rathinam; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-19       Impact factor: 11.205

8.  Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution.

Authors:  Yun-Hee Youm; Hyunwon Yang; Raj Amin; Steven R Smith; Todd Leff; Vishwa D Dixit
Journal:  Aging Cell       Date:  2010-04-01       Impact factor: 9.304

9.  The effects of red cell transfusion donor age on nosocomial infection among trauma patients.

Authors:  Tyler J Loftus; Ryan M Thomas; Travis W Murphy; Linda L Nguyen; Frederick A Moore; Scott C Brakenridge; Philip A Efron; Alicia M Mohr
Journal:  Am J Surg       Date:  2017-07-12       Impact factor: 2.565

10.  Targeting CD137 enhances vaccine-elicited anti-respiratory syncytial virus CD8+ T cell responses in aged mice.

Authors:  Sujin Lee; Robert S Mittler; Martin L Moore
Journal:  J Immunol       Date:  2013-11-27       Impact factor: 5.422
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