Tyler J Loftus1, Ryan M Thomas2, Travis W Murphy3, Linda L Nguyen4, Frederick A Moore5, Scott C Brakenridge6, Philip A Efron7, Alicia M Mohr8. 1. University of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Tyler.Loftus@surgery.ufl.edu. 2. Malcom Randall Veterans Affairs Medical Center Department of Surgery, Gainesville, FL, USA. Electronic address: Ryan.Thomas@surgery.ufl.edu. 3. University of Florida Health Department of Emergency Medicine, Gainesville, FL, USA. Electronic address: Travis.Murphy@surgery.ufl.edu. 4. University of Florida Health College of Medicine, Gainesville, FL, USA. Electronic address: Linda.Nguyen@ufl.edu. 5. University of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Frederick.Moore@surgery.ufl.edu. 6. University of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Scott.Brakenridge@surgery.ufl.edu. 7. University of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Philip.Efron@surgery.ufl.edu. 8. University of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Alicia.Mohr@surgery.ufl.edu.
Abstract
BACKGROUND: We hypothesized that packed red blood cell (PRBC) transfusions from older donors would be associated with fewer nosocomial infections among trauma patients. METHODS: We performed a four-year retrospective analysis of 264 consecutive adult trauma patients who received ≥1 PRBC transfusion during admission. The capacity of donor age to predict nosocomial infection was assessed by logistic regression. RESULTS: Thirty-three percent of all patients developed a nosocomial infection. Donor age was significantly higher among patients with nosocomial infection (40.3 vs. 37.6 years, p = 0.035), and the incidence of infection was directly proportional to donor age. The association between donor age and infection was strongest among recipients age ≥60 years, and was significant on multivariate regression for this cohort (OR 1.07 (95% CI 1.01-1.13), p = 0.024). CONCLUSIONS: Among trauma patients receiving PRBC transfusions, blood from older donors may be associated with increased risk for nosocomial infection.
BACKGROUND: We hypothesized that packed red blood cell (PRBC) transfusions from older donors would be associated with fewer nosocomial infections among traumapatients. METHODS: We performed a four-year retrospective analysis of 264 consecutive adult traumapatients who received ≥1 PRBC transfusion during admission. The capacity of donor age to predict nosocomial infection was assessed by logistic regression. RESULTS: Thirty-three percent of all patients developed a nosocomial infection. Donor age was significantly higher among patients with nosocomial infection (40.3 vs. 37.6 years, p = 0.035), and the incidence of infection was directly proportional to donor age. The association between donor age and infection was strongest among recipients age ≥60 years, and was significant on multivariate regression for this cohort (OR 1.07 (95% CI 1.01-1.13), p = 0.024). CONCLUSIONS: Among traumapatients receiving PRBC transfusions, blood from older donors may be associated with increased risk for nosocomial infection.
Authors: H J Nielsen; C M Reimert; A N Pedersen; N Brünner; L Edvardsen; E Dybkjaer; H Kehlet; P S Skov Journal: Transfusion Date: 1996 Nov-Dec Impact factor: 3.157
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Authors: Dijoia B Darden; Juan C Mira; Maria-Cecilia Lopez; Julie A Stortz; Brittany P Fenner; Lauren S Kelly; Dina C Nacionales; Ashrita Budharaju; Tyler J Loftus; Henry V Baker; Frederick A Moore; Scott C Brakenridge; Lyle L Moldawer; Alicia M Mohr; Philip A Efron Journal: J Trauma Acute Care Surg Date: 2021-10-01 Impact factor: 3.697