OBJECTIVE: The intake of antioxidants was studied for its ability to predict type 2 diabetes. RESEARCH DESIGN AND METHODS: A cohort of 2,285 men and 2,019 women 40-69 years of age and free of diabetes at baseline (1967-1972) was studied. Food consumption during the previous year was estimated using a dietary history interview. The intake of vitamin C, four tocopherols, four tocotrienols, and six carotenoids was calculated. During a 23-year follow-up, a total of 164 male and 219 female incident cases occurred. RESULTS: Vitamin E intake was significantly associated with a reduced risk of type 2 diabetes. The relative risk (RR) of type 2 diabetes between the extreme quartiles of the intake was 0.69 (95% CI 0.51-0.94, P for trend = 0.003). Intakes of alpha-tocopherol, gamma-tocopherol, delta-tocopherol, and beta-tocotrienol were inversely related to a risk of type 2 diabetes. Among single carotenoids, beta-cryptoxanthin intake was significantly associated with a reduced risk of type 2 diabetes (RR 0.58, 95% CI 0.44-0.78, P < 0.001). No association was evident between intake of vitamin C and type 2 diabetes risk. CONCLUSIONS: This study supports the hypothesis that development of type 2 diabetes may be reduced by the intake of antioxidants in the diet.
OBJECTIVE: The intake of antioxidants was studied for its ability to predict type 2 diabetes. RESEARCH DESIGN AND METHODS: A cohort of 2,285 men and 2,019 women 40-69 years of age and free of diabetes at baseline (1967-1972) was studied. Food consumption during the previous year was estimated using a dietary history interview. The intake of vitamin C, four tocopherols, four tocotrienols, and six carotenoids was calculated. During a 23-year follow-up, a total of 164 male and 219 female incident cases occurred. RESULTS:Vitamin E intake was significantly associated with a reduced risk of type 2 diabetes. The relative risk (RR) of type 2 diabetes between the extreme quartiles of the intake was 0.69 (95% CI 0.51-0.94, P for trend = 0.003). Intakes of alpha-tocopherol, gamma-tocopherol, delta-tocopherol, and beta-tocotrienol were inversely related to a risk of type 2 diabetes. Among single carotenoids, beta-cryptoxanthin intake was significantly associated with a reduced risk of type 2 diabetes (RR 0.58, 95% CI 0.44-0.78, P < 0.001). No association was evident between intake of vitamin C and type 2 diabetes risk. CONCLUSIONS: This study supports the hypothesis that development of type 2 diabetes may be reduced by the intake of antioxidants in the diet.
Authors: Latetia V Moore; Kevin W Dodd; Frances E Thompson; Kirsten A Grimm; Sonia A Kim; Kelley S Scanlon Journal: Am J Epidemiol Date: 2015-05-01 Impact factor: 4.897
Authors: J R B Perry; L Ferrucci; S Bandinelli; J Guralnik; R D Semba; N Rice; D Melzer; R Saxena; L J Scott; M I McCarthy; A T Hattersley; E Zeggini; M N Weedon; T M Frayling Journal: Diabetologia Date: 2009-08-07 Impact factor: 10.122
Authors: S van Dieren; C S P M Uiterwaal; Y T van der Schouw; D L van der A; J M A Boer; A Spijkerman; D E Grobbee; J W J Beulens Journal: Diabetologia Date: 2009-09-01 Impact factor: 10.122
Authors: M Kataja-Tuomola; J R Sundell; S Männistö; M J Virtanen; J Kontto; D Albanes; J Virtamo Journal: Diabetologia Date: 2007-11-10 Impact factor: 10.122
Authors: J Arnlöv; B Zethelius; U Risérus; S Basu; C Berne; B Vessby; G Alfthan; J Helmersson Journal: Diabetologia Date: 2008-11-05 Impact factor: 10.122