| Literature DB >> 14741289 |
Uday R Khire1, Donald Bankston, James Barbosa, David R Brittelli, Yolanda Caringal, Robert Carlson, Jacques Dumas, Todd Gane, Sarah L Heald, Barbara Hibner, Jeffrey S Johnson, Michael E Katz, Nancy Kennure, Jill Kingery-Wood, Wendy Lee, Xiao-Gao Liu, Timothy B Lowinger, Ian McAlexander, Mary-Katherine Monahan, Reina Natero, Joel Renick, Bernd Riedl, Hong Rong, Robert N Sibley, Roger A Smith, Donald Wolanin.
Abstract
Bis-aryl ureas have been disclosed previously as a potent class of Raf kinase inhibitors. Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug. Based on this finding, we hypothesize that this portion of the molecule is directed towards the solvent in Raf-1.Entities:
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Year: 2004 PMID： 14741289 DOI： 10.1016/j.bmcl.2003.11.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823