Literature DB >> 14736502

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

Gwendalyn D King1, R Scott Turner.   

Abstract

The cytoplasmic C-terminus of APP plays critical roles in its cellular trafficking and delivery to proteases. Adaptor proteins with phosphotyrosine-binding (PTB) domains, including those in the X11, Fe65, and c-Jun N-terminal kinase (JNK)-interacting protein (JIP) families, bind specifically to the absolutely conserved -YENPTY- motif in the APP C-terminus to regulate its trafficking and processing. Compounds that modulate APP-adaptor protein interactions may inhibit Abeta generation by specifically targeting the substrate (APP) instead of the enzyme (beta- or gamma-secretase). Genetic polymorphisms in (or near) adaptor proteins may influence risk of sporadic AD by interacting with APP in vivo to modulate its trafficking and processing to Abeta.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 14736502     DOI： 10.1016/j.expneurol.2003.10.011

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  60 in total

1.  CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.

Authors:  Kotaro Furusawa; Toshiyuki Takasugi; Yung-Wen Chiu; Yukiko Hori; Taisuke Tomita; Mitsunori Fukuda; Shin-Ichi Hisanaga
Journal:  J Biol Chem       Date:  2019-05-28       Impact factor: 5.157

Review 2.  The amyloid-beta precursor protein: integrating structure with biological function.

Authors:  Constanze Reinhard; Sébastien S Hébert; Bart De Strooper
Journal:  EMBO J       Date:  2005-10-27       Impact factor: 11.598

Review 3.  Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease.

Authors:  Maria-Paz Marzolo; Guojun Bu
Journal:  Semin Cell Dev Biol       Date:  2008-10-17       Impact factor: 7.727

4.  Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65.

Authors:  Eun Jeoung Lee; Sunghee Hyun; Jaesun Chun; Sung Hwa Shin; Sang Sun Kang
Journal:  Exp Mol Med       Date:  2009-08-31       Impact factor: 8.718

Review 5.  Platelets and Alzheimer's disease: Potential of APP as a biomarker.

Authors:  Geneviève Evin; Qiao-Xin Li
Journal:  World J Psychiatry       Date:  2012-12-22

Review 6.  Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.

Authors:  Philip F Copenhaver; Donat Kögel
Journal:  Front Mol Neurosci       Date:  2017-01-31       Impact factor: 5.639

7.  X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.

Authors:  Inderjeet Saluja; Henry Paulson; Ashwin Gupta; R Scott Turner
Journal:  Neurobiol Dis       Date:  2009-07-23       Impact factor: 5.996

8.  Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein.

Authors:  Julien Chapuis; Valérie Vingtdeux; Fabien Campagne; Peter Davies; Philippe Marambaud
Journal:  Hum Mol Genet       Date:  2011-02-28       Impact factor: 6.150

9.  Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain.

Authors:  Jens Radzimanowski; Konrad Beyreuther; Irmgard Sinning; Klemens Wild
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-04-24

10.  Novel mediators of amyloid precursor protein signaling.

Authors:  Andrzej Swistowski; Qiang Zhang; Mark E Orcholski; Danielle Crippen; Cathy Vitelli; Alexei Kurakin; Dale E Bredesen
Journal:  J Neurosci       Date:  2009-12-16       Impact factor: 6.167
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.