Literature DB >> 19041409

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease.

Maria-Paz Marzolo1, Guojun Bu.   

Abstract

Amyloid-beta (Abeta) peptide accumulation in the brain is central to the pathogenesis of Alzheimer's disease (AD). Abeta is produced through proteolytic processing of a transmembrane protein, beta-amyloid precursor protein (APP), by beta- and gamma-secretases. Mounting evidence has demonstrated that alterations in APP cellular trafficking and localization directly impact its processing to Abeta. Members of the low-density lipoprotein receptor family, including LRP, LRP1B, SorLA/LR11, and apoER2, interact with APP and regulate its endocytic trafficking. Additionally, APP trafficking and processing are greatly affected by cellular cholesterol content. In this review, we summarize the current understanding of the roles of lipoprotein receptors and cholesterol in APP trafficking and processing and their implication for AD pathogenesis and therapy.

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Year:  2008        PMID： 19041409      PMCID： PMC2691858          DOI： 10.1016/j.semcdb.2008.10.005

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  162 in total

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Review 2.  Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.

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3.  Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor.

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Review 4.  LRP in amyloid-beta production and metabolism.

Authors:  Guojun Bu; Judy Cam; Celina Zerbinatti
Journal:  Ann N Y Acad Sci       Date:  2006-11       Impact factor: 5.691

5.  Alteration of the LRP1B gene region is associated with high grade of urothelial cancer.

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Journal:  Lab Invest       Date:  2002-05       Impact factor: 5.662

6.  Activation and functional characterization of the mosaic receptor SorLA/LR11.

Authors:  L Jacobsen; P Madsen; C Jacobsen; M S Nielsen; J Gliemann; C M Petersen
Journal:  J Biol Chem       Date:  2001-04-09       Impact factor: 5.157

7.  All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands.

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Authors:  Tracy L Young-Pearse; Jilin Bai; Rui Chang; Jessica B Zheng; Joseph J LoTurco; Dennis J Selkoe
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9.  The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.

Authors:  Judy A Cam; Celina V Zerbinatti; Jane M Knisely; Silva Hecimovic; Yonghe Li; Guojun Bu
Journal:  J Biol Chem       Date:  2004-05-04       Impact factor: 5.157

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  53 in total

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Journal:  Biol Chem       Date:  2010-11       Impact factor: 3.915

Review 2.  Amyloid beta: structure, biology and structure-based therapeutic development.

Authors:  Guo-Fang Chen; Ting-Hai Xu; Yan Yan; Yu-Ren Zhou; Yi Jiang; Karsten Melcher; H Eric Xu
Journal:  Acta Pharmacol Sin       Date:  2017-07-17       Impact factor: 6.150

3.  Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.

Authors:  Lauren K Fong; Max M Yang; Rodrigo Dos Santos Chaves; Sol M Reyna; Vanessa F Langness; Grace Woodruff; Elizabeth A Roberts; Jessica E Young; Lawrence S B Goldstein
Journal:  J Biol Chem       Date:  2018-06-01       Impact factor: 5.157

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Journal:  J Cell Sci       Date:  2010-01-15       Impact factor: 5.285

6.  Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.

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Journal:  J Biol Chem       Date:  2009-10-13       Impact factor: 5.157

7.  Dementia and Alzheimer's disease: a new direction.The 2010 Jay L. Foster Memorial Lecture.

Authors:  Lewis H Kuller; Oscar L Lopez
Journal:  Alzheimers Dement       Date:  2011-09       Impact factor: 21.566

8.  Characterization of secreted proteins of 2-cell mouse embryos cultured in vitro to the blastocyst stage with and without protein supplementation.

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9.  Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

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10.  Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.

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Journal:  PLoS One       Date:  2010-04-13       Impact factor: 3.240
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