Literature DB >> 14731073

Prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRL-lpr/lpr mice.

Yasuhiro Ina1, Kazuo Sakai.   

Abstract

Chronic low-dose-rate gamma irradiation at 0.35 or 1.2 mGy/h prolonged the life span of MRL-lpr/lpr mice carrying a deletion in the apoptosis-regulating Fas gene that markedly shortens life due to severe autoimmune disease. Immunological modifications as indicated by a significant increase of CD8(+) T cells and a significant decrease of CD3(+) CD45R/B220(+) as well as CD45R/B220(+) CD40(+) cells were found in parallel with amelioration of total-body lymphadenopathy, splenomegaly, proteinuria, and kidney and brain syndromes.

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Year:  2004        PMID： 14731073     DOI： 10.1667/rr3120

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  20 in total

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4.  Effects of low dose radiation on immune cells subsets and cytokines in mice.

Authors:  Xiaochang Liu; Zheng Liu; Duo Wang; Yang Han; Sai Hu; Ying Xie; Yike Liu; Maoxiang Zhu; Hua Guan; Yongqing Gu; Ping-Kun Zhou
Journal:  Toxicol Res (Camb)       Date:  2020-05-11       Impact factor: 3.524

5.  The dose window for radiation-induced protective adaptive responses.

Authors:  Ronald E J Mitchel
Journal:  Dose Response       Date:  2009-11-23       Impact factor: 2.658

6.  Immunological mechanism of the low-dose radiation-induced suppression of cancer metastases in a mouse model.

Authors:  Ewa M Nowosielska; Aneta Cheda; Jolanta Wrembel-Wargocka; Marek K Janiak
Journal:  Dose Response       Date:  2009-12-10       Impact factor: 2.658

7.  Enhancement of bio-protective functions by low dose/dose-rate radiation.

Authors:  Kazuo Sakai; Takaharu Nomura; Yasuhiro Ina
Journal:  Dose Response       Date:  2006-09-23       Impact factor: 2.658

8.  Radiation hormesis: the good, the bad, and the ugly.

Authors:  T D Luckey
Journal:  Dose Response       Date:  2006-09-27       Impact factor: 2.658

9.  Production of cytokines by peritoneal macrophages and splenocytes after exposures of mice to low doses of X-rays.

Authors:  Aneta Cheda; Ewa M Nowosielska; Jolanta Wrembel-Wargocka; Marek K Janiak
Journal:  Radiat Environ Biophys       Date:  2007-12-06       Impact factor: 1.925

10.  Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2.

Authors:  Chung Hee Sonn; Jong Rip Choi; Tae-Jin Kim; Young-Bin Yu; Kwanghee Kim; Suk Chul Shin; Gil-Hong Park; Toshiro Shirakawa; Hee Sun Kim; Kyung-Mi Lee
Journal:  J Radiat Res       Date:  2012-08-21       Impact factor: 2.724
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