Literature DB >> 14684340

Structure-activity relationships of novel potent MurF inhibitors.

Yu Gui Gu1, Alan S Florjancic, Richard F Clark, Tianyuan Zhang, Curt S Cooper, David D Anderson, Claude G Lerner, J Owen McCall, Yingna Cai, Candace L Black-Schaefer, Geoffrey F Stamper, Philip J Hajduk, Bruce A Beutel.   

Abstract

A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC(50)=22 approximately 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.

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Year:  2004        PMID： 14684340     DOI： 10.1016/j.bmcl.2003.09.073

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.

Authors:  Kenton L Longenecker; Geoffrey F Stamper; Philip J Hajduk; Elizabeth H Fry; Clarissa G Jakob; John E Harlan; Rohinton Edalji; Diane M Bartley; Karl A Walter; Larry R Solomon; Thomas F Holzman; Yu Gui Gu; Claude G Lerner; Bruce A Beutel; Vincent S Stoll
Journal:  Protein Sci       Date:  2005-12       Impact factor: 6.725

2.  Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency.

Authors:  Claude G Lerner; Stephan J Kakavas; Christian Wagner; Richard T Chang; Philip J Merta; Xiaoan Ruan; Randy E Metzger; Bruce A Beutel
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

3.  Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF.

Authors:  Ellen Z Baum; Steven M Crespo-Carbone; Darren Abbanat; Barbara Foleno; Amy Maden; Raul Goldschmidt; Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

4.  3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.

Authors:  Youjun Yang; Anatoly Severin; Rajiv Chopra; Girija Krishnamurthy; Guy Singh; William Hu; David Keeney; Kristine Svenson; Peter J Petersen; Pornpen Labthavikul; David M Shlaes; Beth A Rasmussen; Amedeo A Failli; Jay S Shumsky; Kristina M K Kutterer; Adam Gilbert; Tarek S Mansour
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 5.  The Gewald multicomponent reaction.

Authors:  Yijun Huang; Alexander Dömling
Journal:  Mol Divers       Date:  2010-02-27       Impact factor: 2.943

Review 6.  Challenges of antibacterial discovery.

Authors:  Lynn L Silver
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

7.  Treponema pallidum putative novel drug target identification and validation: rethinking syphilis therapeutics with plant-derived terpenoids.

Authors:  Upendra N Dwivedi; Sameeksha Tiwari; Priyanka Singh; Swati Singh; Manika Awasthi; Veda P Pandey
Journal:  OMICS       Date:  2015-02

8.  Role of murF in cell wall biosynthesis: isolation and characterization of a murF conditional mutant of Staphylococcus aureus.

Authors:  R G Sobral; A M Ludovice; H de Lencastre; A Tomasz
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

9.  MurF inhibitors with antibacterial activity: effect on muropeptide levels.

Authors:  Ellen Z Baum; Steven M Crespo-Carbone; Barbara D Foleno; Lee D Simon; Jerome Guillemont; Mark Macielag; Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2009-05-26       Impact factor: 5.191

10.  A MurF inhibitor that disrupts cell wall biosynthesis in Escherichia coli.

Authors:  Ellen Z Baum; Steven M Crespo-Carbone; Alexandra Klinger; Barbara D Foleno; Ignatius Turchi; Mark Macielag; Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2007-10-01       Impact factor: 5.191
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