Literature DB >> 14674781

Strategies for heterocyclic construction via novel multicomponent reactions based on isocyanides and nucleophilic carbenes.

Vijay Nair1, C Rajesh, A U Vinod, S Bindu, A R Sreekanth, J S Mathen, Lakshmi Balagopal.   

Abstract

This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.

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Year:  2003        PMID： 14674781     DOI： 10.1021/ar020258p

Source DB:  PubMed          Journal:  Acc Chem Res        ISSN： 0001-4842            Impact factor:   22.384


  35 in total

1.  Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions.

Authors:  Yimin Lu; Wei Zhang
Journal:  QSAR Comb Sci       Date:  2004

2.  One-pot synthesis of γ -spiroiminolactones and γ -dispiroiminolactones using N,N'-disubstituted parabanic acid and thioparabanic acid derivatives.

Authors:  Sakineh Asghari; Mohammad Qandalee; Amir Ali Sarmadi
Journal:  Mol Divers       Date:  2016-09-20       Impact factor: 2.943

3.  Three-component synthesis of functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans.

Authors:  Issa Yavari; Mehdi Sirouspour; Sanaz Souri
Journal:  Mol Divers       Date:  2006-06-16       Impact factor: 2.943

4.  Three-component synthesis of dialkyl 2-(alkylimino-methylene)3- (2,2,5-trimethyl-4,6-dioxo-1,3-dioxan-5-yl)-succinates.

Authors:  Issa Yavari; Hasan Zare; Bita Mohtat
Journal:  Mol Divers       Date:  2006-06-13       Impact factor: 2.943

Review 5.  The status of isocyanide-based multi-component reactions in Iran (2010-2018).

Authors:  Ronak Afshari; Seyyed Emad Hooshmand; Mohammad Taghi Nazeri; Siamak Javanbakht; Ahmad Shaabani; Reza Mohammadian
Journal:  Mol Divers       Date:  2020-02-18       Impact factor: 2.943

6.  Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives "on water".

Authors:  Ahmad Shaabani; Heshmatollah Sepahvand; Shima Ghasemi
Journal:  Mol Divers       Date:  2018-11-21       Impact factor: 2.943

7.  Synthesis of polyfunctionalized acrylates via one-pot reactions of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds.

Authors:  Yan Sun; Jing Sun; Chao-Guo Yan
Journal:  Mol Divers       Date:  2011-11-30       Impact factor: 2.943

8.  Synthesis of functionalized 5-imino-2,5-dihydro-furans through the reaction of isocyanides with activated acetylenes in the presence of ethyl bromopyruvate.

Authors:  Issa Yavari; Zinatossadat Hossaini; Maryam Sabbaghan
Journal:  Mol Divers       Date:  2006-09-12       Impact factor: 2.943

9.  Synthesis of benzimidazole[2.1-b][1,3]oxazine spirooxindoles via three-component reaction of N-benzylbenzimidazole, acetylenedicarboxylates, and N-alkylisatins.

Authors:  Li-Juan Zhang; Chao-Guo Yan
Journal:  Mol Divers       Date:  2014-08-19       Impact factor: 2.943

10.  Reaction between enaminones and acetylenic esters in the presence of triphenylphosphine: a convenient synthesis of alkyl 2(1-benzyl-2,4-dioxo-2,3,4,5,6,7-hexahydro-1H-indol-3-yl)acetates.

Authors:  Farough Nasiri; Massood Bayzidi; Amin Zolali
Journal:  Mol Divers       Date:  2012-08-25       Impact factor: 2.943
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