Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis.

Literature DB >> 30319862

A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis.

Leeseon Kim¹, Yeni Lim², Soo-Yeon Park², You Jin Kim², Oran Kwon², Jin Hee Lee³, Jae-Ho Shin⁴, Yoon Kyoung Yang⁵, Ji Yeon Kim¹.

Abstract

In this study, garlic powder, tomato extract and a mixture of both were analyzed for anti-thrombotic effects using a collagen and epinephrine induced thrombosis model. Rats were randomly assigned to control, thrombosis induced control (COL/EP), garlic powder (G), tomato extract (T) and mixture of garlic powder and tomato extract (GT) groups. Test materials were administered for 7 days and thrombosis was induced by collagen and epinephrine injection. The results showed that G, T, and GT delayed activated partial thromboplastin time and reduced the expression of intracellular adhesion molecule-1 mRNA. Histological analysis of aorta and lung revealed that thrombosis was partially improved by G, T, and GT. Although there was no synergistic effect in GT compared to G and T treatment, this study showed that G, T, and GT have anti-thrombotic effect.

Entities: Disease Species

Keywords: Activate partial thromboplastin time; Anti-thrombotic effect; Garlic; Intracellular adhesion molecule-1; Mixture of garlic and tomato; Tomato

Year: 2018 PMID： 30319862 PMCID： PMC6170286 DOI： 10.1007/s10068-018-0469-z

Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391

25 in total

1. Effects of garlic on blood fluidity and fibrinolytic activity: a randomised, placebo-controlled, double-blind study.

Authors: H Kiesewetter; F Jung; C Mrowietz; G Pindur; M Heiden; E Wenzel; L D Gu
Journal: Br J Clin Pract Suppl Date: 1990-08

2. Attenuation of N-methyl-N'-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination.

Authors: R Kumaraguruparan; K V P Chandra Mohan; S K Abraham; S Nagini
Journal: Life Sci Date: 2005-01-21 Impact factor: 5.037

Review 3. Mechanisms of thrombus formation.

Authors: Bruce Furie; Barbara C Furie
Journal: N Engl J Med Date: 2008-08-28 Impact factor: 91.245

Review 4. Coagulation and atherothrombotic disease.

Authors: Ramzi Ajjan; Peter J Grant
Journal: Atherosclerosis Date: 2005-12-15 Impact factor: 5.162

Review 5. Endothelial cells in physiology and in the pathophysiology of vascular disorders.

Authors: D B Cines; E S Pollak; C A Buck; J Loscalzo; G A Zimmerman; R P McEver; J S Pober; T M Wick; B A Konkle; B S Schwartz; E S Barnathan; K R McCrae; B A Hug; A M Schmidt; D M Stern
Journal: Blood Date: 1998-05-15 Impact factor: 22.113

6. Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway.

Authors: Eun-Wha Son; Sung-Ji Mo; Dong-Kwon Rhee; Suhkneung Pyo
Journal: Int Immunopharmacol Date: 2006-08-17 Impact factor: 4.932

7. Tomato paste supplementation improves endothelial dynamics and reduces plasma total oxidative status in healthy subjects.

Authors: Panagiotis Xaplanteris; Charalambos Vlachopoulos; Panagiota Pietri; Dimitrios Terentes-Printzios; Despina Kardara; Nikolaos Alexopoulos; Konstantinos Aznaouridis; Antigoni Miliou; Christodoulos Stefanadis
Journal: Nutr Res Date: 2012-05-15 Impact factor: 3.315

A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis.

1. Effects of garlic on blood fluidity and fibrinolytic activity: a randomised, placebo-controlled, double-blind study.

2. Attenuation of N-methyl-N'-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination.

Review 3. Mechanisms of thrombus formation.

Review 4. Coagulation and atherothrombotic disease.

Review 5. Endothelial cells in physiology and in the pathophysiology of vascular disorders.

6. Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway.

7. Tomato paste supplementation improves endothelial dynamics and reduces plasma total oxidative status in healthy subjects.

8. Tomato and garlic can modulate azoxymethane-induced colon carcinogenesis in rats.

9. Vascular endothelial cells synthesize nitric oxide from L-arginine.

Review 10. Murine models of vascular thrombosis (Eitzman series).

Review 1. Roles and mechanisms of garlic and its extracts on atherosclerosis: A review.