PURPOSE: To establish fast, high-resolution in vivo cine magnetic resonance imaging (cine-MRI) on a vertical 11.7-T MR system and to investigate the stability of normal and failing mouse hearts in the vertical position. MATERIALS AND METHODS: To optimize the method on a high-field system, various MR-related parameters, such as relaxation times and the need for respiratory gating, were quantitatively investigated. High-resolution cine-MRI was applied to normal mice and to a murine heart failure model. Cardiac functional parameters were compared to matched mice imaged previously on a horizontal MR system. RESULTS: A T(1) of 1.10 +/- 0.27 seconds and a T(2) of 18.5 +/- 3.9 msec were measured for murine myocardial tissue. A quantitative analysis also proved respiratory gating to be essential for obtaining artifact-free cine images in the vertical position at this field strength. Cardiac functional parameters of mice, obtained within one hour, agreed well with those from previous studies of mice in the horizontal position. CONCLUSION: This work shows that MR systems with a vertical bore design can be used to accurately measure cardiac function in both normal and chronically failing mouse hearts within one hour. The increased signal-to-noise ratio (SNR) due to the higher field strength could be exploited to obtain higher temporal and spatial resolution compared to previous studies that were performed on horizontal systems with lower field strengths. Copyright 2003 Wiley-Liss, Inc.
PURPOSE: To establish fast, high-resolution in vivo cine magnetic resonance imaging (cine-MRI) on a vertical 11.7-T MR system and to investigate the stability of normal and failing mouse hearts in the vertical position. MATERIALS AND METHODS: To optimize the method on a high-field system, various MR-related parameters, such as relaxation times and the need for respiratory gating, were quantitatively investigated. High-resolution cine-MRI was applied to normal mice and to a murine heart failure model. Cardiac functional parameters were compared to matched mice imaged previously on a horizontal MR system. RESULTS: A T(1) of 1.10 +/- 0.27 seconds and a T(2) of 18.5 +/- 3.9 msec were measured for murine myocardial tissue. A quantitative analysis also proved respiratory gating to be essential for obtaining artifact-free cine images in the vertical position at this field strength. Cardiac functional parameters of mice, obtained within one hour, agreed well with those from previous studies of mice in the horizontal position. CONCLUSION: This work shows that MR systems with a vertical bore design can be used to accurately measure cardiac function in both normal and chronically failing mouse hearts within one hour. The increased signal-to-noise ratio (SNR) due to the higher field strength could be exploited to obtain higher temporal and spatial resolution compared to previous studies that were performed on horizontal systems with lower field strengths. Copyright 2003 Wiley-Liss, Inc.
Authors: Cristian T Badea; Samuel M Johnston; Ergys Subashi; Yi Qi; Laurence W Hedlund; G Allan Johnson Journal: Med Phys Date: 2010-01 Impact factor: 4.071
Authors: Cristian T Badea; Laurence W Hedlund; Ming De Lin; Julie S Boslego Mackel; Ehsan Samei; G Allan Johnson Journal: Med Phys Date: 2007-05 Impact factor: 4.071
Authors: Cristian T Badea; Laurence W Hedlund; Julie F Boslego Mackel; Lan Mao; Howard A Rockman; G Allan Johnson Journal: Mol Imaging Date: 2007 Jul-Aug Impact factor: 4.488
Authors: Debora Bogani; Catherine Willoughby; Jennifer Davies; Kulvinder Kaur; Ghazala Mirza; Anju Paudyal; Heather Haines; Richard McKeone; Matthew Cadman; Guido Pieles; Jürgen E Schneider; Shoumo Bhattacharya; Andrea Hardy; Patrick M Nolan; Nikos Tripodis; Michael J Depew; Ramya Chandrasekara; Gimara Duncan; Paul T Sharpe; Andy Greenfield; Paul Denny; Steve D M Brown; Jiannis Ragoussis; Ruth M Arkell Journal: Proc Natl Acad Sci U S A Date: 2005-08-18 Impact factor: 11.205