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Literature DB >> 14630939

Template boundary definition in mammalian telomerase.

Abstract

Telomerase uses a short template sequence in its intrinsic RNA component to synthesize telomere repeats. Disruption of the helix P1b in human telomerase RNA or alteration of its distance from the template resulted in telomerase copying residues past the normal template boundary both in vivo and in vitro. Therefore, helix P1b is important for template boundary definition in human telomerase. Mouse telomerase RNA lacks helix P1b, and the boundary is established at 2 nt downstream of the 5'-end. The divergent structure of boundary definition elements in mammals, yeast, and ciliates suggests diverse mechanisms for template boundary definition in telomerase.

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Year: 2003 PMID： 14630939 PMCID： PMC280623 DOI： 10.1101/gad.1140303

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

29 in total

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Journal: Cell Date: 1991-10-18 Impact factor: 41.582

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Journal: Nature Date: 1989-01-26 Impact factor: 49.962

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Authors: C W Greider; E H Blackburn
Journal: Cell Date: 1985-12 Impact factor: 41.582

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Authors: C Autexier; C W Greider
Journal: Genes Dev Date: 1995-09-15 Impact factor: 11.361

5. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.

Authors: Jiunn-Liang Chen; Kay Keyer Opperman; Carol W Greider
Journal: Nucleic Acids Res Date: 2002-01-15 Impact factor: 16.971

6. Template boundary definition in Tetrahymena telomerase.

Authors: Cary K Lai; Michael C Miller; Kathleen Collins
Journal: Genes Dev Date: 2002-02-15 Impact factor: 11.361

7. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility.

Authors: Jiunn-Liang Chen; Carol W Greider
Journal: EMBO J Date: 2003-01-15 Impact factor: 11.598

8. Specific association of human telomerase activity with immortal cells and cancer.

Authors: N W Kim; M A Piatyszek; K R Prowse; C B Harley; M D West; P L Ho; G M Coviello; W E Wright; S L Weinrich; J W Shay
Journal: Science Date: 1994-12-23 Impact factor: 47.728

9. Ciliate telomerase RNA structural features.

Authors: M McCormick-Graham; D P Romero
Journal: Nucleic Acids Res Date: 1995-04-11 Impact factor: 16.971

10. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.

Authors: J Lingner; L L Hendrick; T R Cech
Journal: Genes Dev Date: 1994-08-15 Impact factor: 11.361

83 in total

1. Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation.

Authors: Aaron R Robart; Kathleen Collins
Journal: Mol Cell Date: 2011-04-21 Impact factor: 17.970

2. An emerging consensus for telomerase RNA structure.

Authors: Jiunn-Liang Chen; Carol W Greider
Journal: Proc Natl Acad Sci U S A Date: 2004-10-04 Impact factor: 11.205

Review 3. Telomerase: an RNP enzyme synthesizes DNA.

Authors: Elizabeth H Blackburn; Kathleen Collins
Journal: Cold Spring Harb Perspect Biol Date: 2011-05-01 Impact factor: 10.005

4. The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation.

Authors: Alec N Sexton; Kathleen Collins
Journal: Mol Cell Biol Date: 2010-12-13 Impact factor: 4.272

5. Protein-RNA interaction restricts telomerase from running through the stop sign.

Authors: Linghe Xi; Thomas R Cech
Journal: Nat Struct Mol Biol Date: 2015-11 Impact factor: 15.369

6. Functional analysis of the pseudoknot structure in human telomerase RNA.

Authors: Jiunn-Liang Chen; Carol W Greider
Journal: Proc Natl Acad Sci U S A Date: 2005-04-22 Impact factor: 11.205

7. Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme.

Authors: Doreen D Cunningham; Kathleen Collins
Journal: Mol Cell Biol Date: 2005-06 Impact factor: 4.272

8. Telomerase can act as a template- and RNA-independent terminal transferase.

Authors: Neal F Lue; Dimitry Bosoy; Tara J Moriarty; Chantal Autexier; Brian Altman; Siyang Leng
Journal: Proc Natl Acad Sci U S A Date: 2005-06-30 Impact factor: 11.205

9. Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer.

Authors: Tara J Moriarty; Delphine T Marie-Egyptienne; Chantal Autexier
Journal: Mol Cell Biol Date: 2004-05 Impact factor: 4.272

10. Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach.

Authors: Yang Li; Joshua D Podlevsky; Manja Marz; Xiaodong Qi; Steve Hoffmann; Peter F Stadler; Julian J-L Chen
Journal: RNA Date: 2013-04-12 Impact factor: 4.942