Literature DB >> 2463488

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.

C W Greider1, E H Blackburn.   

Abstract

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

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Year:  1989        PMID： 2463488     DOI： 10.1038/337331a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  542 in total

1.  The length of telomeric G-rich strand 3'-overhang measured by oligonucleotide ligation assay.

Authors:  G Cimino-Reale; E Pascale; E Battiloro; G Starace; R Verna; E D'Ambrosio
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

2.  Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro.

Authors:  V M Tesmer; L P Ford; S E Holt; B C Frank; X Yi; D L Aisner; M Ouellette; J W Shay; W E Wright
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

3.  Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase.

Authors:  J Xia; Y Peng; I S Mian; N F Lue
Journal:  Mol Cell Biol       Date:  2000-07       Impact factor: 4.272

4.  Interference footprinting analysis of telomerase elongation complexes.

Authors:  S Benjamin; N Baran; H Manor
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

5.  Three telomerases with completely non-telomeric template replacements are catalytically active.

Authors:  T L Ware; H Wang; E H Blackburn
Journal:  EMBO J       Date:  2000-06-15       Impact factor: 11.598

6.  Functional requirement of p23 and Hsp90 in telomerase complexes.

Authors:  S E Holt; D L Aisner; J Baur; V M Tesmer; M Dy; M Ouellette; J B Trager; G B Morin; D O Toft; J W Shay; W E Wright; M A White
Journal:  Genes Dev       Date:  1999-04-01       Impact factor: 11.361

7.  Molecular cytogenetics investigation of the telomeres in a case of Philadelphia positive B-ALL with a single telomere expansion.

Authors:  K Krejcí; J Stentoft; J Koch
Journal:  Neoplasia       Date:  1999-12       Impact factor: 5.715

8.  Template definition by Tetrahymena telomerase reverse transcriptase.

Authors:  M C Miller; J K Liu; K Collins
Journal:  EMBO J       Date:  2000-08-15       Impact factor: 11.598

9.  Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.

Authors:  April J Livengood; Arthur J Zaug; Thomas R Cech
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

10.  Role for telomere cap structure in meiosis.

Authors:  H Maddar; N Ratzkovsky; A Krauskopf
Journal:  Mol Biol Cell       Date:  2001-10       Impact factor: 4.138
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