Literature DB >> 11850404

Template boundary definition in Tetrahymena telomerase.

Cary K Lai1, Michael C Miller, Kathleen Collins.   

Abstract

Telomerase elongates chromosome ends by addition of telomeric DNA repeats. The telomerase ribonucleoprotein can copy only a short template sequence within the telomerase RNA subunit. Here, we identify a region of telomerase RNA that is necessary for both correct 5' template boundary definition and high affinity telomerase reverse transcriptase (TERT) interaction. We also demonstrate that TERT mutants in the RNA binding domain compromise both 5' boundary definition and RNA binding. Our results indicate that sequence-specific interaction of a telomerase RNA element with the TERT RNA binding domain, not the active site motifs, defines the template boundary.

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Year:  2002        PMID： 11850404      PMCID： PMC155345          DOI： 10.1101/gad.962602

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  16 in total

1.  Template boundary in a yeast telomerase specified by RNA structure.

Authors:  Y Tzfati; T B Fulton; J Roy; E H Blackburn
Journal:  Science       Date:  2000-05-05       Impact factor: 47.728

Review 2.  Telomeres and their control.

Authors:  M J McEachern; A Krauskopf; E H Blackburn
Journal:  Annu Rev Genet       Date:  2000       Impact factor: 16.830

3.  Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability.

Authors:  C Guiducci; M A Cerone; S Bacchetti
Journal:  Oncogene       Date:  2001-02-08       Impact factor: 9.867

4.  A conserved secondary structure for telomerase RNA.

Authors:  D P Romero; E H Blackburn
Journal:  Cell       Date:  1991-10-18       Impact factor: 41.582

5.  RNA binding domain of telomerase reverse transcriptase.

Authors:  C K Lai; J R Mitchell; K Collins
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272

6.  Boundary elements of the Tetrahymena telomerase RNA template and alignment domains.

Authors:  C Autexier; C W Greider
Journal:  Genes Dev       Date:  1995-09-15       Impact factor: 11.361

7.  Runaway telomere elongation caused by telomerase RNA gene mutations.

Authors:  M J McEachern; E H Blackburn
Journal:  Nature       Date:  1995-08-03       Impact factor: 49.962

8.  Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase.

Authors:  T M Bryan; K J Goodrich; T R Cech
Journal:  Mol Cell       Date:  2000-08       Impact factor: 17.970

9.  Telomerase RNA function in recombinant Tetrahymena telomerase.

Authors:  J D Licht; K Collins
Journal:  Genes Dev       Date:  1999-05-01       Impact factor: 11.361

10.  Ciliate telomerase RNA structural features.

Authors:  M McCormick-Graham; D P Romero
Journal:  Nucleic Acids Res       Date:  1995-04-11       Impact factor: 16.971
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  63 in total

1.  Telomerase recognizes its template by using an adjacent RNA motif.

Authors:  Michael C Miller; Kathleen Collins
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-07       Impact factor: 11.205

2.  Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation.

Authors:  Aaron R Robart; Kathleen Collins
Journal:  Mol Cell       Date:  2011-04-21       Impact factor: 17.970

3.  Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans.

Authors:  Douglas X Mason; Elizabeth Goneska; Carol W Greider
Journal:  Mol Cell Biol       Date:  2003-08       Impact factor: 4.272

4.  An emerging consensus for telomerase RNA structure.

Authors:  Jiunn-Liang Chen; Carol W Greider
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-04       Impact factor: 11.205

5.  Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants.

Authors:  Andrea J Berman; Anne R Gooding; Thomas R Cech
Journal:  Mol Cell Biol       Date:  2010-08-16       Impact factor: 4.272

Review 6.  Telomerase: an RNP enzyme synthesizes DNA.

Authors:  Elizabeth H Blackburn; Kathleen Collins
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-05-01       Impact factor: 10.005

7.  Protein-RNA interaction restricts telomerase from running through the stop sign.

Authors:  Linghe Xi; Thomas R Cech
Journal:  Nat Struct Mol Biol       Date:  2015-11       Impact factor: 15.369

8.  A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase.

Authors:  Ramadevi Prathapam; Keren L Witkin; Catherine M O'Connor; Kathleen Collins
Journal:  Nat Struct Mol Biol       Date:  2005-02-06       Impact factor: 15.369

9.  Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme.

Authors:  Doreen D Cunningham; Kathleen Collins
Journal:  Mol Cell Biol       Date:  2005-06       Impact factor: 4.272

10.  A novel pseudoknot element is essential for the action of a yeast telomerase.

Authors:  Yehuda Tzfati; Zachary Knight; Jagoree Roy; Elizabeth H Blackburn
Journal:  Genes Dev       Date:  2003-06-27       Impact factor: 11.361
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