Literature DB >> 14604233

Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR.

Jin-Lan Zhang1, Qing-Min Che, Shou-Zhuo Li, Tong-Hui Zhou.   

Abstract

Scutellarin is the major active constituent of Scutellaria barbata D. The metabolism of scutellarin has been investigated in rats. The solid-phase extraction and HPLC-DAD methods were established to separate and analyse metabolites. Five metabolites (M1-M5) were identified by enzymatic hydrolysis, HPLC-DAD, HPLC-MS and HPLC-NMR. M1 and M3 were conjugates of scutellarin with two sulfate groups, which have not been reported in natural plants. M2 was scutellarin; M4 was 6-methyl-scutellarin; and M5 was 6-methyl-scutellarein. The metabolic pathway was proposed.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14604233     DOI： 10.1080/1028602031000105858

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  9 in total

1.  Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces.

Authors:  Jian-feng Xing; Hai-sheng You; Ya-lin Dong; Jun Lu; Si-ying Chen; Hui-fang Zhu; Qian Dong; Mao-yi Wang; Wei-hua Dong
Journal:  Acta Pharmacol Sin       Date:  2011-04-25       Impact factor: 6.150

2.  Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats.

Authors:  J M Huang; W Y Weng; X B Huang; Y H Ji; E Chen
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2005 Jul-Sep       Impact factor: 2.441

3.  Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine.

Authors:  Mei Li; Yong Zheng; Feng-ying Shan; Jing Zhou; Tao Gong; Zhi-rong Zhang
Journal:  Acta Pharmacol Sin       Date:  2013-06-17       Impact factor: 6.150

4.  Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle.

Authors:  Vivian Chen; Richard E Staub; Scott Baggett; Ramesh Chimmani; Mary Tagliaferri; Isaac Cohen; Emma Shtivelman
Journal:  PLoS One       Date:  2012-01-17       Impact factor: 3.240

5.  Synthesis and bio-activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease.

Authors:  Li-Hua Qian; Nian-Guang Li; Yu-Ping Tang; Li Zhang; Hao Tang; Zhen-Jiang Wang; Li Liu; Shu-Lin Song; Jian-Ming Guo; An-Wei Ding
Journal:  Int J Mol Sci       Date:  2011-11-18       Impact factor: 5.923

6.  Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative.

Authors:  Ting Gu; Yue Zhong; Yu-Ting Lu; Ying Sun; Ze-Xi Dong; Wen-Yu Wu; Zhi-Hao Shi; Nian-Guang Li; Xin Xue; Fang Fang; He-Min Li; Yu-Ping Tang
Journal:  Molecules       Date:  2017-06-21       Impact factor: 4.411

7.  An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin.

Authors:  Ze-Xi Dong; Nian-Guang Li; Peng-Xuan Zhang; Ting Gu; Wen-Yu Wu; Zhi-Hao Shi
Journal:  Molecules       Date:  2016-02-25       Impact factor: 4.411

8.  Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats.

Authors:  Lihua Qian; Minzhe Shen; Hao Tang; Yuping Tang; Li Zhang; Yifan Fu; Qianping Shi; Nian-Guang Li
Journal:  Molecules       Date:  2012-09-06       Impact factor: 4.411

9.  A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Erigeron breviscapus Extract.

Authors:  Siying Chen; Mei Li; Yueting Li; Hejia Hu; Ying Li; Yong Huang; Lin Zheng; Yuan Lu; Jie Hu; Yanyu Lan; Aimin Wang; Yongjun Li; Zipeng Gong; Yonglin Wang
Journal:  Molecules       Date:  2018-07-21       Impact factor: 4.411
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.