Literature DB >> 14596970

Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs.

Kathleen A Ruggero1, Laura K Schroeder, Paul C Schreckenberger, Alexander S Mankin, John P Quinn.   

Abstract

Resistance to linezolid among Enterococcus faecium and Enterococcus faecalis isolates has been reported in patients who receive a prolonged course of the drug. We report two cases of linezolid-resistant Enterococcus faecalis that occurred in patients who previously received linezolid for infections with vancomycin-resistant Enterococcus faecium. Both isolates had the G2576U mutation in the 23S rRNA previously reported in isolates of Enterococcus faecium. The number of gene copies mutated in the 23S rRNA correlated with the level of resistance.

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Year:  2003        PMID： 14596970     DOI： 10.1016/s0732-8893(03)00153-6

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  15 in total

1.  Molecular detection of linezolid resistance in Enterococcus faecium and Enterococcus faecalis by use of 5' nuclease real-time PCR compared to a modified classical approach.

Authors:  Guido Werner; Birgit Strommenger; Ingo Klare; Wolfgang Witte
Journal:  J Clin Microbiol       Date:  2004-11       Impact factor: 5.948

2.  Agents for the Treatment of Multidrug-resistant Gram-positive Endocarditis.

Authors:  Jennifer K Long
Journal:  Curr Infect Dis Rep       Date:  2005-07       Impact factor: 3.725

3.  Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.

Authors:  Marc H Scheetz; Stephanie A Knechtel; Michael Malczynski; Michael J Postelnick; Chao Qi
Journal:  Antimicrob Agents Chemother       Date:  2008-04-07       Impact factor: 5.191

4.  Sensitivity to detergents and plasmid curing in Enterococcus faecalis.

Authors:  Jacqueline Keyhani; Ezzatollah Keyhani; Farnoosh Attar; Azam Haddadi
Journal:  J Ind Microbiol Biotechnol       Date:  2005-06-30       Impact factor: 3.346

5.  Tedizolid susceptibility in linezolid- and vancomycin-resistant Enterococcus faecium isolates.

Authors:  E-M Klupp; A Both; C Belmar Campos; H Büttner; C König; M Christopeit; M Christner; M Aepfelbacher; H Rohde
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-08-15       Impact factor: 3.267

6.  Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance.

Authors:  Jie Feng; Andréanne Lupien; Hélène Gingras; Jessica Wasserscheid; Ken Dewar; Danielle Légaré; Marc Ouellette
Journal:  Genome Res       Date:  2009-04-06       Impact factor: 9.043

7.  Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).

Authors:  Jeffrey B Locke; Mark Hilgers; Karen Joy Shaw
Journal:  Antimicrob Agents Chemother       Date:  2009-09-14       Impact factor: 5.191

8.  Use of pyrosequencing to identify point mutations in domain V of 23S rRNA genes of linezolid-resistant Staphylococcus aureus and Staphylococcus epidermidis.

Authors:  W Zhu; F C Tenover; J Limor; D Lonsway; D Prince; W M Dunne; J B Patel
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2007-03       Impact factor: 3.267

9.  Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineage.

Authors:  Maria Grazia Bonora; Maurizio Solbiati; Erminia Stepan; Antonella Zorzi; Aldo Luzzani; Maria Rosaria Catania; Roberta Fontana
Journal:  J Clin Microbiol       Date:  2006-03       Impact factor: 5.948

10.  Comparison of testing methods for detection of decreased linezolid susceptibility due to G2576T mutation of the 23S rRNA gene in Enterococcus faecium and Enterococcus faecalis.

Authors:  Chao Qi; Xiaotian Zheng; Arlene Obias; Marc H Scheetz; Michael Malczynski; John R Warren
Journal:  J Clin Microbiol       Date:  2006-03       Impact factor: 5.948
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