Literature DB >> 14582164

Nuclear inheritance of erythromycin resistance in human cells: new class of mitochondrial protein synthesis mutants.

C J Doersen1, E J Stanbridge.   

Abstract

The characterization of two new erythromycin-resistant mutants of HeLa cells is described. The strains ERY2305 and ERY2309 both exhibited resistance to erythromycin in growth assays and cell-free mitochondrial protein synthesis assays. The erythromycin resistance phenotype could not be transferred by cybridization. The mutation appeared to be encoded in the nucleus and inherited as a recessive trait. These two mutants, therefore, represent a new class of erythromycin-resistant mutants in human cells that is distinct from the cytoplasmically inherited mutation in strain ERY2301 described previously.

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Year:  1982        PMID： 14582164      PMCID： PMC369845          DOI： 10.1128/mcb.2.6.694-700.1982

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  25 in total

Review 1.  The mitochondrial genome of yeast.

Authors:  P Borst; L A Grivell
Journal:  Cell       Date:  1978-11       Impact factor: 41.582

2.  Cytoplasmic transfer of a determinant for chloramphenicol resistance between mammalian cell lines.

Authors:  E Munro; R L Siegel; I W Craig; W S Sly
Journal:  Proc R Soc Lond B Biol Sci       Date:  1978-04-13

3.  Cytoplasmic inheritance of chloramphenicol resistance in mouse tissue culture cells.

Authors:  C L Bunn; D C Wallace; J M Eisenstadt
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

4.  Reversible tenfod reduction in mitochondria DNA content of human cells treated with ethidium bromide.

Authors:  A Wiseman; G Attardi
Journal:  Mol Gen Genet       Date:  1978-11-16

5.  Improved techniques for the induction of mammalian cell hybridization by polyethylene glycol.

Authors:  R L Davidson; P S Gerald
Journal:  Somatic Cell Genet       Date:  1976-03

6.  The molecular basis of emetine resistance in Chinese hamster ovary cells: alteration in the 40S ribosomal subunit.

Authors:  R S Gupta; L Siminovitch
Journal:  Cell       Date:  1977-01       Impact factor: 41.582

7.  Cytoplasmic inheritance of rutamycin resistance in mouse fibroblasts.

Authors:  T Lichtor; G S Getz
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

8.  Carbomycin resistance in mouse L cells.

Authors:  C L Bunn; J M Eisenstadt
Journal:  Somatic Cell Genet       Date:  1977-11

9.  Mitotic segregation of cytoplasmic determinants for chloramphenicol resistance in mammalian cells II: Fusions with human cell lines.

Authors:  D C Wallace; C L Bunn; J M Eisenstadt
Journal:  Somatic Cell Genet       Date:  1977-01

10.  Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells.

Authors:  D C Wallace; C L Bunn; J M Eisenstadt
Journal:  J Cell Biol       Date:  1975-10       Impact factor: 10.539
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