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Literature DB >> 14570400

A metabolic basis for Alzheimer disease.

George Perry¹, Akihiko Nunomura, Arun K Raina, Gjumrakch Aliev, Sandra L Siedlak, Peggy L R Harris, Gemma Casadesus, Robert B Petersen, William Bligh-Glover, Elizabeth Balraj, Grace J Petot, Mark A Smith.

Abstract

Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.

Entities: Disease

Mesh：

Year: 2003 PMID： 14570400 DOI： 10.1023/a:1025678510480

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

21 in total

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Authors: Adam D Cash; Gjumrakch Aliev; Sandra L Siedlak; Akihiko Nunomura; Hisashi Fujioka; Xiongwei Zhu; Arun K Raina; Harry V Vinters; Massimo Tabaton; Anne B Johnson; Manuel Paula-Barbosa; Jesus Avíla; Paul K Jones; Rudy J Castellani; Mark A Smith; George Perry
Journal: Am J Pathol Date: 2003-05 Impact factor: 4.307

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Authors: John Hardy; Dennis J Selkoe
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Authors: Naji Tabet; David Mantle; Zuzana Walker; Martin Orrell
Journal: Int Psychogeriatr Date: 2002-03 Impact factor: 3.878

10. Elevated levels of tau in cerebrospinal fluid: implications for the antemortem diagnosis of Alzheimer's disease elevated levels of tau in cerebrospinal fluid: implications for the antemortem diagnosis of Alzheimer's disease.

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23 in total

Review 1. Natural products as a source of Alzheimer's drug leads.

Authors: Philip Williams; Analia Sorribas; Melanie-Jayne R Howes
Journal: Nat Prod Rep Date: 2010-11-12 Impact factor: 13.423

2. Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.

Authors: Eric M Blalock; Heather M Buechel; Jelena Popovic; James W Geddes; Philip W Landfield
Journal: J Chem Neuroanat Date: 2011-07-02 Impact factor: 3.052

Review 3. Indices of metabolic dysfunction and oxidative stress.

Authors: Gemma Casadesus; Paula I Moreira; Akihiko Nunomura; Sandra L Siedlak; William Bligh-Glover; Elizabeth Balraj; Grace Petot; Mark A Smith; George Perry
Journal: Neurochem Res Date: 2007-03-07 Impact factor: 3.996

4. Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet.

Authors: Christy L White; Paul J Pistell; Megan N Purpera; Sunita Gupta; Sun-Ok Fernandez-Kim; Taylor L Hise; Jeffrey N Keller; Donald K Ingram; Christopher D Morrison; Annadora J Bruce-Keller
Journal: Neurobiol Dis Date: 2009-04-15 Impact factor: 5.996