BACKGROUND: Thermodilution coronary flow reserve (CFRthermo) is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wire and is based on the ability of the pressure transducer to also measure temperature changes. Whether CFRthermo correlates well enough with absolute flow-derived CFR (CFRflow) to replace Doppler wire-derived CFR (CFRDoppler) remains unclear. METHODS AND RESULTS: In an open-chest pig model, CFRthermo was measured in the left anterior descending (LAD) artery and compared with CFRDoppler and CFRflow, measured with an external flow probe placed around the LAD. In 9 pigs, CFR was measured simultaneously by all 3 means in the normal LAD and after creation of an epicardial LAD stenosis. To determine the added effect of microvascular disease, measurements of flow reserve were also performed after disruption of the coronary microcirculation with embolized microspheres. Intracoronary papaverine (20 mg) was used to induce hyperemia. In a total of 61 paired measurements, CFRthermo correlated strongly with the reference standard CFRflow (r=0.85, P<0.001). CFRDoppler correlated less well with CFRflow (r=0.72, P<0.001). Bland-Altman analysis showed a closer agreement between CFRthermo and CFRflow. CONCLUSIONS: CFRthermo correlates better with CFRflow than does CFRDoppler.
BACKGROUND: Thermodilution coronary flow reserve (CFRthermo) is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wire and is based on the ability of the pressure transducer to also measure temperature changes. Whether CFRthermo correlates well enough with absolute flow-derived CFR (CFRflow) to replace Doppler wire-derived CFR (CFRDoppler) remains unclear. METHODS AND RESULTS: In an open-chest pig model, CFRthermo was measured in the left anterior descending (LAD) artery and compared with CFRDoppler and CFRflow, measured with an external flow probe placed around the LAD. In 9 pigs, CFR was measured simultaneously by all 3 means in the normal LAD and after creation of an epicardial LAD stenosis. To determine the added effect of microvascular disease, measurements of flow reserve were also performed after disruption of the coronary microcirculation with embolized microspheres. Intracoronary papaverine (20 mg) was used to induce hyperemia. In a total of 61 paired measurements, CFRthermo correlated strongly with the reference standard CFRflow (r=0.85, P<0.001). CFRDoppler correlated less well with CFRflow (r=0.72, P<0.001). Bland-Altman analysis showed a closer agreement between CFRthermo and CFRflow. CONCLUSIONS: CFRthermo correlates better with CFRflow than does CFRDoppler.
Authors: A Bukowska; M Hammwöhner; A Sixdorf; L Schild; I Wiswedel; F-W Röhl; C Wolke; U Lendeckel; C Aderkast; S Bochmann; R K Chilukoti; J Mostertz; P Bramlage; A Goette Journal: Br J Pharmacol Date: 2012-06 Impact factor: 8.739
Authors: Rahn Ilsar; Chirapan Chawantanpipat; Kim H Chan; Timothy A Dobbins; Richard Waugh; Annemarie Hennessy; David S Celermajer; Martin K C Ng Journal: PLoS One Date: 2010-03-09 Impact factor: 3.240
Authors: Yuhei Kobayashi; William F Fearon; Yasuhiro Honda; Shigemitsu Tanaka; Vedant Pargaonkar; Peter J Fitzgerald; David P Lee; Marcia Stefanick; Alan C Yeung; Jennifer A Tremmel Journal: JACC Cardiovasc Interv Date: 2015-09 Impact factor: 11.195
Authors: So Ra Park; Young Ran Kang; Myeng Ki Seo; Min Kyeng Kang; Jong Hyen Cho; Yon Jung An; Chung Hwan Kwak; Sek Jae Hwang; Young Hun Jung; Jin Yong Hwang Journal: Korean Circ J Date: 2009-08-27 Impact factor: 3.243