RATIONALE AND OBJECTIVES: This study was designed to determine the optimal contrast protocol for 4-detector-row computed tomography angiography of the heart. METHODS:Sixty patients were randomly assigned to 1 of 4 groups with 300 and 400 mg/mL iodine concentrations and 2.5 and 3.5 mL/s flow rates. Contrast density was measured in the left ventricular cavity and coronary arteries. RESULTS: Low iodine concentration injected at slow flow rate (0.75 g iodine/s) resulted in acceptable contrast enhancement in only 53.8% of the patients. There was no significant difference between low contrast concentration injected at high flow rate and high contrast concentration injected at slow flow rate ( approximately 1 g iodine/s). High contrast concentration administered with high flow rates (1.4 g iodine/s) may result in an enhancement above 350 Hounsfield units (HU) and interfere with coronary calcifications. CONCLUSIONS: The injection of approximately 1 g iodine/s resulted in an optimal (250-300 HU) contrast enhancement for cardiac 4-detector-row computed tomography.
RCT Entities:
RATIONALE AND OBJECTIVES: This study was designed to determine the optimal contrast protocol for 4-detector-row computed tomography angiography of the heart. METHODS: Sixty patients were randomly assigned to 1 of 4 groups with 300 and 400 mg/mL iodine concentrations and 2.5 and 3.5 mL/s flow rates. Contrast density was measured in the left ventricular cavity and coronary arteries. RESULTS: Low iodine concentration injected at slow flow rate (0.75 g iodine/s) resulted in acceptable contrast enhancement in only 53.8% of the patients. There was no significant difference between low contrast concentration injected at high flow rate and high contrast concentration injected at slow flow rate ( approximately 1 g iodine/s). High contrast concentration administered with high flow rates (1.4 g iodine/s) may result in an enhancement above 350 Hounsfield units (HU) and interfere with coronary calcifications. CONCLUSIONS: The injection of approximately 1 g iodine/s resulted in an optimal (250-300 HU) contrast enhancement for cardiac 4-detector-row computed tomography.
Authors: Andreas H Mahnken; Annabella Rauscher; Ernst Klotz; Georg Mühlenbruch; Marco Das; Rolf W Günther; Joachim E Wildberger Journal: Eur Radiol Date: 2006-11-18 Impact factor: 5.315
Authors: F Tatsugami; T Kanamoto; G Nakai; Y Takeda; H Morita; I Morinaga; S Yoshikawa; I Narabayashi Journal: Br J Radiol Date: 2009-06-08 Impact factor: 3.039
Authors: Aju P Pazhenkottil; Lars Husmann; Ronny R Buechel; Bernhard A Herzog; René Nkoulou; Irene A Burger; Andrea Vetterli; Ines Valenta; Jelena R Ghadri; Patrick von Schulthess; Philipp A Kaufmann Journal: Int J Cardiovasc Imaging Date: 2010-02-04 Impact factor: 2.357