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Literature DB >> 14564721

Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids.

Abstract

Several crystalline N-hydroxysuccinimide esters of short- and long-chain fatty acids have been synthesized. These compounds react with free amino acids to form preferentially N-acylamino acids. The reaction of the N-hydroxysuccinimide esters with hydroxylamine and the behavior of the N-acylamino acids on thin-layer chromatography are described.

Entities: Chemical

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Substances：

Year: 1967 PMID： 14564721

Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922

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Cited

37 in total

1. Quantitative correlation between the residual activity of beta-hexosaminidase A and arylsulfatase A and the severity of the resulting lysosomal storage disease.

Authors: P Leinekugel; S Michel; E Conzelmann; K Sandhoff
Journal: Hum Genet Date: 1992-03 Impact factor: 4.132

2. Synthesis of palmitoyl derivatives of insulin and their biological activities.

Authors: M Hashimoto; K Takada; Y Kiso; S Muranishi
Journal: Pharm Res Date: 1989-02 Impact factor: 4.200

3. Partial purification of a glucocorticoid receptor.

Authors: D Failla; G M Tomkins; D V Santi
Journal: Proc Natl Acad Sci U S A Date: 1975-10 Impact factor: 11.205

4. Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics.

Authors: Mieke A Catry; Annemieke Madder
Journal: Molecules Date: 2007-01-31 Impact factor: 4.411

5. Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles.

Authors: Sandra Reichstetter; Gerardo M Castillo; Israel Rubinstein; Akiko Nishimoto-Ashfield; Manshun Lai; Cynthia C Jones; Aryamitra A Banerjee; Aryamitra Banjeree; Alex Lyubimov; Duane C Bloedow; Alexei Bogdanov; Elijah M Bolotin
Journal: Pharm Res Date: 2012-12-07 Impact factor: 4.200

10. Development of new lipophilic derivatives of tetragastrin: physicochemical characteristics and intestinal absorption of acyl-tetragastrin derivatives in rats.

Authors: T Tenma; E Yodoya; S Tashima; T Fujita; M Murakami; A Yamamoto; S Muranishi
Journal: Pharm Res Date: 1993-10 Impact factor: 4.200

Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids.

1. Quantitative correlation between the residual activity of beta-hexosaminidase A and arylsulfatase A and the severity of the resulting lysosomal storage disease.

2. Synthesis of palmitoyl derivatives of insulin and their biological activities.

3. Partial purification of a glucocorticoid receptor.

4. Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics.

5. Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles.

6. A liposome-based therapeutic vaccine against beta -amyloid plaques on the pancreas of transgenic NORBA mice.

7. Purification and properties of 2-furoyl-coenzyme A hydroxylase from Pseudomonas putida F2.

8. The dietary regulation of acyltransferase and desaturase activities in microsomal membranes of rat liver.

9. Determination of butoxyacetic acid and N-butoxyacetyl-glutamine in urine of lacquerers exposed to 2-butoxyethanol.

10. Development of new lipophilic derivatives of tetragastrin: physicochemical characteristics and intestinal absorption of acyl-tetragastrin derivatives in rats.