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Literature DB >> 1454830

A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen.

Abstract

Like all aliphatic amines, the polyamines spermine and spermidine are physical quenchers of singlet molecular oxygen (1O2*). The rate constants of these processes were determined in vitro with photochemically generated 1O2* and the hydrocarbon rubrene as substrate, in pyridine. At millimolar concentration, spermine and spermidine should quench 1O2* in vivo and prevent it from damaging DNA. It is proposed that a biological function of polyamines is the protection of replicating DNA against oxidative damage.

Entities: Chemical

Mesh：

Substances：

Year: 1992 PMID： 1454830 PMCID： PMC50563 DOI： 10.1073/pnas.89.23.11426

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

1. Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen.

Authors: A U Khan; P Di Mascio; M H Medeiros; T Wilson
Journal: Proc Natl Acad Sci U S A Date: 1992-12-01 Impact factor: 11.205

2. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.

Authors: B N AMES; D T DUBIN
Journal: J Biol Chem Date: 1960-03 Impact factor: 5.157

3. Chloroperoxidase generation of singlet Delta molecular oxygen observed directly by spectroscopy in the 1- to 1.6-mum region.

Authors: A U Khan; P Gebauer; L P Hager
Journal: Proc Natl Acad Sci U S A Date: 1983-09 Impact factor: 11.205

4. Polyamine deficiency reduces the rate of DNA replication fork movement in Escherichia coli.

Authors: L E Geiger; D R Morris
Journal: Nature Date: 1978-04-20 Impact factor: 49.962

5. 4-Thiouridine and the conformation of E. coli tRNA induced by spermidine.

Authors: F Pochon; S S Cohen
Journal: Biochem Biophys Res Commun Date: 1972-05-26 Impact factor: 3.575

6. Antiarthritic gold compounds effectively quench electronically excited singlet oxygen.

Authors: E J Corey; M M Mehrotra; A U Khan
Journal: Science Date: 1987-04-03 Impact factor: 47.728

Review 7. Polyamines.

Authors: C W Tabor; H Tabor
Journal: Annu Rev Biochem Date: 1984 Impact factor: 23.643

8. Polyamine binding to phospholipid vesicles and inhibition of lipid peroxidation.

Authors: B Tadolini; L Cabrini; L Landi; E Varani; P Pasquali
Journal: Biochem Biophys Res Commun Date: 1984-07-31 Impact factor: 3.575

9. Singlet oxygen production by chloroperoxidase-hydrogen peroxide-halide systems.

Authors: J R Kanofsky
Journal: J Biol Chem Date: 1984-05-10 Impact factor: 5.157

Review 10. Biological consequences associated with DNA oxidation mediated by singlet oxygen.

Authors: J Piette
Journal: J Photochem Photobiol B Date: 1991-12 Impact factor: 6.252

30 in total

1. Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen.

Authors: A U Khan; P Di Mascio; M H Medeiros; T Wilson
Journal: Proc Natl Acad Sci U S A Date: 1992-12-01 Impact factor: 11.205

2. Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure.

Authors: Olav Albert Christophersen
Journal: Microb Ecol Health Dis Date: 2012-02-01

A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen.

1. Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen.

2. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.

3. Chloroperoxidase generation of singlet Delta molecular oxygen observed directly by spectroscopy in the 1- to 1.6-mum region.

4. Polyamine deficiency reduces the rate of DNA replication fork movement in Escherichia coli.

5. 4-Thiouridine and the conformation of E. coli tRNA induced by spermidine.

6. Antiarthritic gold compounds effectively quench electronically excited singlet oxygen.

Review 7. Polyamines.

8. Polyamine binding to phospholipid vesicles and inhibition of lipid peroxidation.

9. Singlet oxygen production by chloroperoxidase-hydrogen peroxide-halide systems.

Review 10. Biological consequences associated with DNA oxidation mediated by singlet oxygen.

1. Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen.

2. Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure.

3. Effect of chemical chaperones on glucose-induced lysozyme modifications.

4. Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.

5. The natural polyamine spermine functions directly as a free radical scavenger.

6. Hydroxyl radical scavenging and singlet oxygen quenching properties of polyamines.

7. Polyamines in growth and dimorphism of Paracoccidioides brasiliensis.

Review 8. Proline mechanisms of stress survival.

9. Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress.

10. Effect of Sex on Biomarker Response in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.