Literature DB >> 9736703

The natural polyamine spermine functions directly as a free radical scavenger.

H C Ha1, N S Sirisoma, P Kuppusamy, J L Zweier, P M Woster, R A Casero.   

Abstract

The polyamines are small organic cations that are absolutely required for eukaryotic cell growth. Although their growth requirements are well established, the molecular functions of the polyamines are ill-defined. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. The polyamine spermine, which is normally found in millimolar concentrations in the nucleus, is shown here to function directly as a free radical scavenger, and adducts formed as a result of this function are identified. These data suggest that spermine is a major natural intracellular compound capable of protecting DNA from free radical attack.

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Year:  1998        PMID： 9736703      PMCID： PMC21609          DOI： 10.1073/pnas.95.19.11140

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen.

Authors:  A U Khan; P Di Mascio; M H Medeiros; T Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

Review 2.  Antioxidant response element.

Authors:  A K Jaiswal
Journal:  Biochem Pharmacol       Date:  1994-08-03       Impact factor: 5.858

Review 3.  Polyamines as targets for therapeutic intervention.

Authors:  L J Marton; A E Pegg
Journal:  Annu Rev Pharmacol Toxicol       Date:  1995       Impact factor: 13.820

4.  DNA damage resulting from the oxidation of hydroquinone by copper: role for a Cu(II)/Cu(I) redox cycle and reactive oxygen generation.

Authors:  Y Li; M A Trush
Journal:  Carcinogenesis       Date:  1993-07       Impact factor: 4.944

5.  Use of 4-fluoro-L-ornithine to monitor metabolic flux through the polyamine biosynthetic pathway.

Authors:  D Kramer; J Stanek; P Diegelman; U Regenass; P Schneider; C W Porter
Journal:  Biochem Pharmacol       Date:  1995-10-26       Impact factor: 5.858

6.  When are metal ion-dependent hydroxyl and alkoxyl radical adducts of 5,5-dimethyl-1-pyrroline N-oxide artifacts?

Authors:  P M Hanna; W Chamulitrat; R P Mason
Journal:  Arch Biochem Biophys       Date:  1992-08-01       Impact factor: 4.013

7.  Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.

Authors:  J L Zweier; R Broderick; P Kuppusamy; S Thompson-Gorman; G A Lutty
Journal:  J Biol Chem       Date:  1994-09-30       Impact factor: 5.157

8.  ESR evidence for the generation of reactive oxygen species from the copper-mediated oxidation of the benzene metabolite, hydroquinone: role in DNA damage.

Authors:  Y Li; P Kuppusamy; J L Zweier; M A Trush
Journal:  Chem Biol Interact       Date:  1995-02       Impact factor: 5.192

9.  Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor.

Authors:  M H Park; H L Cooper; J E Folk
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

10.  Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

Authors:  J M Dypbukt; M Ankarcrona; M Burkitt; A Sjöholm; K Ström; S Orrenius; P Nicotera
Journal:  J Biol Chem       Date:  1994-12-02       Impact factor: 5.157
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  166 in total

1.  Retinol-induced elevation of ornithine decarboxylase activity in cultured rat Sertoli cells is attenuated by free radical scavenger and by iron chelator.

Authors:  F Klamt; F Dal-Pizzol; N C Ribeiro; E A Bernard; M S Benfato; J C Moreira
Journal:  Mol Cell Biochem       Date:  2000-05       Impact factor: 3.396

2.  Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea.

Authors:  C A Mackintosh; A E Pegg
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

3.  L-arginyl-3,4-spermidine is neuroprotective in several in vitro models of neurodegeneration and in vivo ischaemia without suppressing synaptic transmission.

Authors:  Barclay Morrison; Ashley K Pringle; Terence McManus; John Ellard; Mark Bradley; Francesco Signorelli; Fausto Iannotti; Lars E Sundstrom
Journal:  Br J Pharmacol       Date:  2002-12       Impact factor: 8.739

4.  Characterisation of a novel class of polyamine-based neuroprotective compounds.

Authors:  Ashley K Pringle; Barclay Morrison; Mark Bradley; Fausto Iannotti; Lars E Sundstrom
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-08-06       Impact factor: 3.000

5.  Leukocytes and oxidative stress: dilemma for sperm function and male fertility.

Authors:  Ralf R Henkel
Journal:  Asian J Androl       Date:  2010-11-15       Impact factor: 3.285

6.  Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure.

Authors:  Olav Albert Christophersen
Journal:  Microb Ecol Health Dis       Date:  2012-02-01

7.  RpoS-regulated genes of Escherichia coli identified by random lacZ fusion mutagenesis.

Authors:  Somalinga R V Vijayakumar; Mark G Kirchhof; Cheryl L Patten; Herb E Schellhorn
Journal:  J Bacteriol       Date:  2004-12       Impact factor: 3.490

8.  Spermine facilitates recovery from drought but does not confer drought tolerance in transgenic rice plants expressing Datura stramonium S-adenosylmethionine decarboxylase.

Authors:  Ariadna Peremarti; Ludovic Bassie; Paul Christou; Teresa Capell
Journal:  Plant Mol Biol       Date:  2009-02-21       Impact factor: 4.076

9.  A NAC Transcription Factor Represses Putrescine Biosynthesis and Affects Drought Tolerance.

Authors:  Hao Wu; Bing Fu; Peipei Sun; Chang Xiao; Ji-Hong Liu
Journal:  Plant Physiol       Date:  2016-09-23       Impact factor: 8.340

10.  Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.

Authors:  Yang Ou; Shang-Jui Wang; Dawei Li; Bo Chu; Wei Gu
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-03       Impact factor: 11.205
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