Literature DB >> 14538105

Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA).

A Parmar1, H Kumar, S S Marwaha, J F Kennedy.   

Abstract

This article elaborates on the important recent developments in the enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA), which is the basic raw material for the industrial production of semisynthetic penicillins such as amoxycillin and ampicillin. Particular emphasis is placed on the improvements in purification, stability, and immobilization of the enzymes, (i.e. penicillin acylases) used for these transformations.

Entities:  

Year:  2000        PMID： 14538105     DOI： 10.1016/s0734-9750(00)00039-2

Source DB:  PubMed          Journal:  Biotechnol Adv        ISSN： 0734-9750            Impact factor:   14.227


  10 in total

1.  Crystallization and X-ray structure analysis of a thermostable penicillin G acylase from Alcaligenes faecalis.

Authors:  Nishant Kumar Varshney; R Suresh Kumar; Zoya Ignatova; Asmita Prabhune; Archana Pundle; Eleanor Dodson; C G Suresh
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-02-15

2.  Genetic modification of the penicillin G acylase surface to improve its reversible immobilization on ionic exchangers.

Authors:  Tamara Montes; Valeria Grazú; Fernando López-Gallego; Juan A Hermoso; Jose L García; Isabel Manso; Beatriz Galán; Ramón González; Roberto Fernández-Lafuente; José M Guisán
Journal:  Appl Environ Microbiol       Date:  2006-11-10       Impact factor: 4.792

Review 3.  Actinomycetes: A Never-Ending Source of Bioactive Compounds-An Overview on Antibiotics Production.

Authors:  Davide De Simeis; Stefano Serra
Journal:  Antibiotics (Basel)       Date:  2021-04-22

4.  Functional expression of a penicillin acylase from the extreme thermophile Thermus thermophilus HB27 in Escherichia coli.

Authors:  Leticia L Torres; Eloy R Ferreras; Angel Cantero; Aurelio Hidalgo; José Berenguer
Journal:  Microb Cell Fact       Date:  2012-08-09       Impact factor: 5.328

Review 5.  A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA.

Authors:  Anirban Nandi; Sharadwata Pan; Ravichandra Potumarthi; Michael K Danquah; Indira P Sarethy
Journal:  J Anal Methods Chem       Date:  2014-02-24       Impact factor: 2.193

Review 6.  Exploitation of E. coli for the production of penicillin G amidase: a tool for the synthesis of semisynthetic β-lactam antibiotics.

Authors:  Krishika Sambyal; Rahul Vikram Singh
Journal:  J Genet Eng Biotechnol       Date:  2021-10-15

Review 7.  Active pharmaceutical ingredient (API) chemicals: a critical review of current biotechnological approaches.

Authors:  Vinod Kumar; Vasudha Bansal; Aravind Madhavan; Manoj Kumar; Raveendran Sindhu; Mukesh Kumar Awasthi; Parameswaran Binod; Saurabh Saran
Journal:  Bioengineered       Date:  2022-02       Impact factor: 3.269

Review 8.  Strategies to Improve the Biosynthesis of β-Lactam Antibiotics by Penicillin G Acylase: Progress and Prospects.

Authors:  Xin Pan; Lei Xu; Yaru Li; Sihua Wu; Yong Wu; Wenping Wei
Journal:  Front Bioeng Biotechnol       Date:  2022-07-18

9.  Hydrogel coated monoliths for enzymatic hydrolysis of penicillin G.

Authors:  K M de Lathouder; M W Smeltink; A J J Straathof; M A Paasman; E J A X van de Sandt; F Kapteijn; J A Moulijn
Journal:  J Ind Microbiol Biotechnol       Date:  2008-04-22       Impact factor: 3.346

10.  Activating a Silver Lipoate Nanocluster with a Penicillin Backbone Induces a Synergistic Effect against S. aureus Biofilm.

Authors:  Humberto H Lara; David M Black; Christine Moon; Elizabeth Orr; Priscilla Lopez; Marcos M Alvarez; Glen Baghdasarian; Jose Lopez-Ribot; Robert L Whetten
Journal:  ACS Omega       Date:  2019-12-13
  10 in total

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