Literature DB >> 14533479

Targeted disruption of Streptomyces globisporus lndF and lndL cyclase genes involved in landomycin E biosynthesis.

B Ostash1, Y Rebets, V Yuskevich, A Luzhetskyy, V Tkachenko, V Fedorenko.   

Abstract

Streptomyces globisporus strains with knockouts in lndF and lndL genes, previously identified as possibly encoding cyclases governing cyclization of the nascent oligoketide ('polyketide') chain during the biosynthesis of the antitumor angucycline landomycin E, were prepared. On combining the results of sequence analysis and HPLC of extracts from mutant strains, lndL was suggested to control the first cyclization-aromatization event and lndF to be responsible for the 3rd-4th ring formation.

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Year:  2003        PMID： 14533479     DOI： 10.1007/BF02931329

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.629


  6 in total

Review 1.  Biosynthesis of polyketides (other than actinomycete macrolides).

Authors:  B J Rawlings
Journal:  Nat Prod Rep       Date:  1999-08       Impact factor: 13.423

Review 2.  Polyketide biosynthesis: a millennium review.

Authors:  J Staunton; K J Weissman
Journal:  Nat Prod Rep       Date:  2001-08       Impact factor: 13.423

3.  Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.

Authors:  M J Lozano; L L Remsing; L M Quirós; A F Braña; E Fernández; C Sánchez; C Méndez; J Rohr; J A Salas
Journal:  J Biol Chem       Date:  2000-02-04       Impact factor: 5.157

4.  Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase.

Authors:  B Shen; C R Hutchinson
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

5.  [Interspecies conjugation of Escherichia coli-Streptomyces globisporus 1912 using integrative plasmid pSET152 and its derivatives].

Authors:  A N Luzhetskiĭ; B E Ostash; V A Fedorenko
Journal:  Genetika       Date:  2001-10

Review 6.  Hybrid antibiotics.

Authors:  V Bĕhal
Journal:  Folia Microbiol (Praha)       Date:  2003       Impact factor: 2.629
  6 in total
  5 in total

1.  RNA-Seq and RNA immunoprecipitation analyses of the transcriptome of Streptomyces coelicolor identify substrates for RNase III.

Authors:  Marcha L Gatewood; Patricia Bralley; M Ryan Weil; George H Jones
Journal:  J Bacteriol       Date:  2012-03-02       Impact factor: 3.490

2.  Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.

Authors:  Lili Zhu; Bohdan Ostash; Uwe Rix; Mohammad Nur-E-Alam; Almuth Mayers; Andriy Luzhetskyy; Carmen Mendez; Jose A Salas; Andreas Bechthold; Victor Fedorenko; Jürgen Rohr
Journal:  J Org Chem       Date:  2005-01-21       Impact factor: 4.354

Review 3.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

4.  Generation of landomycin D-producing strain Streptomyces globisporus LD3.

Authors:  B Ostash; I Kozarevska; V Fedorenko
Journal:  Folia Microbiol (Praha)       Date:  2005       Impact factor: 2.629

5.  Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A.

Authors:  Irina Voitsekhovskaia; Constanze Paulus; Charlotte Dahlem; Yuriy Rebets; Suvd Nadmid; Josef Zapp; Denis Axenov-Gribanov; Christian Rückert; Maxim Timofeyev; Jörn Kalinowski; Alexandra K Kiemer; Andriy Luzhetskyy
Journal:  Microorganisms       Date:  2020-05-07
  5 in total

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