Literature DB >> 12744073

Hybrid antibiotics.

V Bĕhal1.   

Abstract

Hybrid antibiotics that do not occur in nature have been obtained by combining structural genes of antibiotic producers. Some of these substances were effective against pathogenic microorganisms resistant against antibiotics produced by the parent strains. The majority of hybrid antibiotics were obtained by combining genes encoding polyketide synthases. Hybrid peptides with new biological properties have also been synthesized.

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Year:  2003        PMID： 12744073     DOI： 10.1007/BF02931272

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.629


  28 in total

1.  Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.

Authors:  H Ikeda; T Nonomiya; M Usami; T Ohta; S Omura
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Activities of synthetic hybrid peptides against anaerobic bacteria: aspects of methodology and stability.

Authors:  H Oh; M Hedberg; D Wade; C Edlund
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

Review 3.  Bioactive products from Streptomyces.

Authors:  V Bĕhal
Journal:  Adv Appl Microbiol       Date:  2000       Impact factor: 5.086

4.  Antibacterial and antimalarial properties of peptides that are cecropin-melittin hybrids.

Authors:  H G Boman; D Wade; I A Boman; B Wåhlin; R B Merrifield
Journal:  FEBS Lett       Date:  1989-12-18       Impact factor: 4.124

Review 5.  Constructing polyketides: from collie to combinatorial biosynthesis.

Authors:  R Bentley; J W Bennett
Journal:  Annu Rev Microbiol       Date:  1999       Impact factor: 15.500

6.  A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes.

Authors:  T Schupp; C Toupet; B Cluzel; S Neff; S Hill; J J Beck; J M Ligon
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

7.  Production of a new hybrid anthracycline 4-O-methylepelmycin by heterologous expression of dnrK in epelmycin-producing Streptomyces violaceus.

Authors:  Y Miyamoto; S Ohta; O Johdo; Y Nagamatsu; A Yoshimoto
Journal:  J Antibiot (Tokyo)       Date:  2000-08       Impact factor: 2.649

8.  Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases.

Authors:  R Pieper; G Luo; D E Cane; C Khosla
Journal:  Nature       Date:  1995-11-16       Impact factor: 49.962

9.  Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes.

Authors:  B Feng; E Friedlin; G A Marzluf
Journal:  Curr Genet       Date:  1995-03       Impact factor: 3.886

10.  Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.

Authors:  J Niemi; K Ylihonko; J Hakala; R Pärssinen; A Kopio; P Mäntsälä
Journal:  Microbiology       Date:  1994-06       Impact factor: 2.777
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  2 in total

Review 1.  Alternative sources of biologically active substances.

Authors:  V Bĕhal
Journal:  Folia Microbiol (Praha)       Date:  2003       Impact factor: 2.099

2.  Targeted disruption of Streptomyces globisporus lndF and lndL cyclase genes involved in landomycin E biosynthesis.

Authors:  B Ostash; Y Rebets; V Yuskevich; A Luzhetskyy; V Tkachenko; V Fedorenko
Journal:  Folia Microbiol (Praha)       Date:  2003       Impact factor: 2.629
  2 in total

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