Literature DB >> 14528306

The microRNA-producing enzyme Dicer1 is essential for zebrafish development.

Erno Wienholds1, Marco J Koudijs, Freek J M van Eeden, Edwin Cuppen, Ronald H A Plasterk.   

Abstract

MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.

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Year:  2003        PMID： 14528306     DOI： 10.1038/ng1251

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  169 in total

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