Literature DB >> 21197118

Synthesis of Novel Functionalized 4-Aza-2,3-Didehydropodophyllotoxin Derivatives with Potential Antitumor Activity.

Ajay Kumar1, Antonio E Alegria.   

Abstract

Novel n class="Chemical">arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50-70% were obtained.

Entities:  

Year:  2010        PMID： 21197118      PMCID： PMC3010172          DOI： 10.1002/jhet.467

Source DB:  PubMed          Journal:  J Heterocycl Chem        ISSN： 0022-152X            Impact factor:   2.193


  13 in total

1.  A multicomponent reaction for the one-pot synthesis of 4-aza-2,3-didehydropodophyllotoxin and derivatives.

Authors:  Christophe Tratrat; Sylviane Giorgi-Renault; Henri-Philippe Husson
Journal:  Org Lett       Date:  2002-09-19       Impact factor: 6.005

2.  Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives.

Authors:  Xiao-Kang Zhu; Jian Guan; Zhiyan Xiao; L Mark Cosentino; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem       Date:  2004-08-01       Impact factor: 3.641

3.  Pharmacokinetics and pharmacodynamics of the new podophyllotoxin derivative NK 611. A study by the AIO groups PHASE-I and APOH.

Authors:  K Mross; A Hüttmann; K Herbst; A R Hanauske; T Schilling; C Manegold; K Burk; D K Hossfeld
Journal:  Cancer Chemother Pharmacol       Date:  1996       Impact factor: 3.333

4.  Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells.

Authors:  J D Loike; S B Horwitz
Journal:  Biochemistry       Date:  1976-12-14       Impact factor: 3.162

5.  4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: simple aza-podophyllotoxin analogues possessing potent cytotoxicity.

Authors:  Y Hitotsuyanagi; M Fukuyo; K Tsuda; M Kobayashi; A Ozeki; H Itokawa; K Takeya
Journal:  Bioorg Med Chem Lett       Date:  2000-02-21       Impact factor: 2.823

6.  Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.

Authors:  Zhiyan Xiao; Yun-De Xiao; Jun Feng; Alexander Golbraikh; Alexander Tropsha; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2002-05-23       Impact factor: 7.446

7.  Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.

Authors:  Z Q Wang; Y H Kuo; D Schnur; J P Bowen; S Y Liu; F S Han; J Y Chang; Y C Cheng; K H Lee
Journal:  J Med Chem       Date:  1990-09       Impact factor: 7.446

8.  Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer.

Authors:  T Utsugi; J Shibata; Y Sugimoto; K Aoyagi; K Wierzba; T Kobunai; T Terada; T Oh-hara; T Tsuruo; Y Yamada
Journal:  Cancer Res       Date:  1996-06-15       Impact factor: 12.701

9.  Antibacterial activity of synthetic precursors of podophyllotoxin.

Authors:  N Nanjundaswamy; S Satishi; K M Lokanatha Rai; S Shashikanth; K A Raveesha
Journal:  Int J Biomed Sci       Date:  2007-06
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  5 in total

1.  N-hydroxyethyl-4-aza-didehydropodophyllotoxin derivatives as potential antitumor agents.

Authors:  Ajay Kumar; Vineet Kumar; Antonio E Alegria; Sanjay V Malhotra
Journal:  Eur J Pharm Sci       Date:  2011-05-13       Impact factor: 4.384

Review 2.  Advancements in tetronic acid chemistry. Part 2: Use as a simple precursor to privileged heterocyclic motifs.

Authors:  Moaz M Abdou; Rasha A El-Saeed; Khaled M Elattar; Zeynel Seferoğlu; John Boukouvalas
Journal:  Mol Divers       Date:  2016-06-27       Impact factor: 2.943

Review 3.  Synthetic and application perspectives of azapodophyllotoxins: alternative scaffolds of podophyllotoxin.

Authors:  A Kumar; V Kumar; A E Alegria; S V Malhotra
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

4.  Biological Activity of N-Hydroxyethyl-4-aza-2,3-didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells.

Authors:  Christian Vélez; Beatriz Zayas; Ajay Kumar
Journal:  Open J Med Chem       Date:  2014-03

5.  Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.

Authors:  Mirko Andreoli; Marco Persico; Ajay Kumar; Nausicaa Orteca; Vineet Kumar; Antonella Pepe; Sakkarapalayam Mahalingam; Antonio E Alegria; Lella Petrella; Laima Sevciunaite; Alessia Camperchioli; Marisa Mariani; Antonio Di Dato; Ettore Novellino; Giovanni Scambia; Sanjay V Malhotra; Cristiano Ferlini; Caterina Fattorusso
Journal:  J Med Chem       Date:  2014-09-26       Impact factor: 7.446
  5 in total

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