Literature DB >> 14517257

Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences.

Matthias Baumann1, Adamantios Mamais, Fraser McBlane, Hua Xiao, Joan Boyes.   

Abstract

A key component in the regulation of V(D)J recombination is control of the accessibility of RAG proteins to recombination signal sequences (RSS). Nucleosomes are known to inhibit this accessibility. We show here that the signal sequence itself represses accessibility by causing nucleosome positioning over the RSS. This positioning is mediated, in vitro and in vivo, by the conserved nonamer of the RSS. Consistent with this strong positioning, nucleosomes at RSSs are resistant to remodelling by nucleosome sliding. In vivo we find that consensus RSSs are preferentially protected, whereas those that lack a consensus nonamer, including some cryptic RSSs, fail to position nucleosomes. Decreased protection of these non-consensus RSSs correlates with their increased use in recombination assays. We therefore suggest that nucleosome positioning by RSSs provides a previously unanticipated level of protection and regulation of V(D)J recombination.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14517257      PMCID： PMC204470          DOI： 10.1093/emboj/cdg487

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  42 in total

Review 1.  The mechanism and regulation of chromosomal V(D)J recombination.

Authors:  Craig H Bassing; Wojciech Swat; Frederick W Alt
Journal:  Cell       Date:  2002-04       Impact factor: 41.582

2.  Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development.

Authors:  Steven T Kosak; Jane A Skok; Kay L Medina; Roy Riblet; Michelle M Le Beau; Amanda G Fisher; Harinder Singh
Journal:  Science       Date:  2002-04-05       Impact factor: 47.728

3.  Developmental stage specificity of the lymphoid V(D)J recombination activity.

Authors:  M R Lieber; J E Hesse; K Mizuuchi; M Gellert
Journal:  Genes Dev       Date:  1987-10       Impact factor: 11.361

4.  Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

Authors:  J F McBlane; D C van Gent; D A Ramsden; C Romeo; C A Cuomo; M Gellert; M A Oettinger
Journal:  Cell       Date:  1995-11-03       Impact factor: 41.582

5.  RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

Authors:  M J Sadofsky; J E Hesse; D C van Gent; M Gellert
Journal:  Genes Dev       Date:  1995-09-01       Impact factor: 11.361

6.  Reconstitution of mononucleosomes: characterization of distinct particles that differ in the position of the histone core.

Authors:  W Linxweiler; W Hörz
Journal:  Nucleic Acids Res       Date:  1984-12-21       Impact factor: 16.971

7.  DNA bending and its relation to nucleosome positioning.

Authors:  H R Drew; A A Travers
Journal:  J Mol Biol       Date:  1985-12-20       Impact factor: 5.469

8.  Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site.

Authors:  J Boyes; G Felsenfeld
Journal:  EMBO J       Date:  1996-05-15       Impact factor: 11.598

9.  Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro.

Authors:  P Stanhope-Baker; K M Hudson; A L Shaffer; A Constantinescu; M S Schlissel
Journal:  Cell       Date:  1996-06-14       Impact factor: 41.582

10.  The role of a positioned nucleosome at the Drosophila melanogaster hsp26 promoter.

Authors:  Q Lu; L L Wallrath; S C Elgin
Journal:  EMBO J       Date:  1995-10-02       Impact factor: 11.598
View more
  29 in total

1.  Both high mobility group (HMG)-boxes and the acidic tail of HMGB1 regulate recombination-activating gene (RAG)-mediated recombination signal synapsis and cleavage in vitro.

Authors:  Serge Bergeron; Tina Madathiparambil; Patrick C Swanson
Journal:  J Biol Chem       Date:  2005-07-01       Impact factor: 5.157

2.  A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.

Authors:  Yun Liu; Ramesh Subrahmanyam; Tirtha Chakraborty; Ranjan Sen; Stephen Desiderio
Journal:  Immunity       Date:  2007-10-11       Impact factor: 31.745

3.  Interplay between DNA methylation and transcription factor availability: implications for developmental activation of the mouse Myogenin gene.

Authors:  Daniela Palacios; Dennis Summerbell; Peter W J Rigby; Joan Boyes
Journal:  Mol Cell Biol       Date:  2010-05-24       Impact factor: 4.272

Review 4.  The center of accessibility: Dβ control of V(D)J recombination.

Authors:  Michael L Sikes; Ruth E McMillan; Justin M Bradshaw
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2010-10-02       Impact factor: 4.291

5.  Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo.

Authors:  Hrisavgi D Kondilis-Mangum; Robin Milley Cobb; Oleg Osipovich; Sruti Srivatsan; Eugene M Oltz; Michael S Krangel
Journal:  J Immunol       Date:  2010-05-17       Impact factor: 5.422

6.  Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus.

Authors:  Bernard Khor; Grace K Mahowald; Katrina Khor; Barry P Sleckman
Journal:  Mol Immunol       Date:  2008-12-13       Impact factor: 4.407

7.  Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.

Authors:  Sandhya R Pulivarthy; Mattia Lion; Guray Kuzu; Adam G W Matthews; Mark L Borowsky; John Morris; Robert E Kingston; Jonathan H Dennis; Michael Y Tolstorukov; Marjorie A Oettinger
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-03       Impact factor: 11.205

Review 8.  RAG: a recombinase diversified.

Authors:  Adam G W Matthews; Marjorie A Oettinger
Journal:  Nat Immunol       Date:  2009-07-21       Impact factor: 25.606

9.  RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.

Authors:  Adam G W Matthews; Alex J Kuo; Santiago Ramón-Maiques; Sunmi Han; Karen S Champagne; Dmitri Ivanov; Mercedes Gallardo; Dylan Carney; Peggie Cheung; David N Ciccone; Kay L Walter; Paul J Utz; Yang Shi; Tatiana G Kutateladze; Wei Yang; Or Gozani; Marjorie A Oettinger
Journal:  Nature       Date:  2007-11-21       Impact factor: 49.962

10.  Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells.

Authors:  Anne E Lieberman; Masayuki Kuraoka; Marco Davila; Garnett Kelsoe; Lindsay G Cowell
Journal:  BMC Immunol       Date:  2009-06-25       Impact factor: 3.615
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.