BACKGROUND: Gastric cancer is one of the most frequent malignancies in the world, ranking fifth in the Netherlands as a cause of cancer death. Surgery is the only curative treatment for advanced cases, but results of gastrectomy largely depend on the stage of the disease. A better understanding of the mechanisms of progression from a preneoplastic condition through intraepithelial neoplasia to invasive cancer may provide information relevant to designing focused prevention strategies. METHODS: Because the pattern of chromosomal aberrations in precursors of gastric cancer is unclear, 11 gastric polyps with intraepithelial neoplasia (three hyperplastic polyps and eight adenomas) were analysed by microarray comparative genomic hybridisation to study chromosomal instability in precursors of gastric cancer. RESULTS: Chromosomal aberrations were detected in all specimens. Adenomas showed no more chromosomal aberrations than did the hyperplastic polyps. The most frequent aberrations were gain of 7q36 and 20q12, and loss of 5q14-q21 in the adenomas, and loss of 15q11-14, 1p21-31, and 21q11-21.2 in the hyperplastic polyps. The most frequent chromosomal aberration in common to both types was loss of 9p21.3. CONCLUSION: Hyperplastic polyps showed many chromosomal aberrations, confirming that neoplastic transformation can occur in these lesions. These observations are consistent with the existence of two morphologically and genetically distinct pathways to gastric cancer-the hyperplastic polyp pathway and the (intestinal type) adenoma pathway. The relative contribution of each to gastric carcinogenesis in general, and how they compare to patterns of chromosomal aberrations in the more prevalent flat foci of intraepithelial neoplasia remain to be determined.
BACKGROUND:Gastric cancer is one of the most frequent malignancies in the world, ranking fifth in the Netherlands as a cause of cancer death. Surgery is the only curative treatment for advanced cases, but results of gastrectomy largely depend on the stage of the disease. A better understanding of the mechanisms of progression from a preneoplastic condition through intraepithelial neoplasia to invasive cancer may provide information relevant to designing focused prevention strategies. METHODS: Because the pattern of chromosomal aberrations in precursors of gastric cancer is unclear, 11 gastric polyps with intraepithelial neoplasia (three hyperplastic polyps and eight adenomas) were analysed by microarray comparative genomic hybridisation to study chromosomal instability in precursors of gastric cancer. RESULTS: Chromosomal aberrations were detected in all specimens. Adenomas showed no more chromosomal aberrations than did the hyperplastic polyps. The most frequent aberrations were gain of 7q36 and 20q12, and loss of 5q14-q21 in the adenomas, and loss of 15q11-14, 1p21-31, and 21q11-21.2 in the hyperplastic polyps. The most frequent chromosomal aberration in common to both types was loss of 9p21.3. CONCLUSION:Hyperplastic polyps showed many chromosomal aberrations, confirming that neoplastic transformation can occur in these lesions. These observations are consistent with the existence of two morphologically and genetically distinct pathways to gastric cancer-the hyperplastic polyp pathway and the (intestinal type) adenoma pathway. The relative contribution of each to gastric carcinogenesis in general, and how they compare to patterns of chromosomal aberrations in the more prevalent flat foci of intraepithelial neoplasia remain to be determined.
Authors: A M Snijders; N Nowak; R Segraves; S Blackwood; N Brown; J Conroy; G Hamilton; A K Hindle; B Huey; K Kimura; S Law; K Myambo; J Palmer; B Ylstra; J P Yue; J W Gray; A N Jain; D Pinkel; D G Albertson Journal: Nat Genet Date: 2001-11 Impact factor: 38.330
Authors: Ajay N Jain; Taku A Tokuyasu; Antoine M Snijders; Richard Segraves; Donna G Albertson; Daniel Pinkel Journal: Genome Res Date: 2002-02 Impact factor: 9.043
Authors: D G Albertson; B Ylstra; R Segraves; C Collins; S H Dairkee; D Kowbel; W L Kuo; J W Gray; D Pinkel Journal: Nat Genet Date: 2000-06 Impact factor: 38.330
Authors: Mario Hermsen; Cindy Postma; Jan Baak; Marjan Weiss; Anna Rapallo; Andrea Sciutto; Guido Roemen; Jan-Willem Arends; Richard Williams; Walter Giaretti; Anton De Goeij; Gerrit Meijer Journal: Gastroenterology Date: 2002-10 Impact factor: 22.682
Authors: Tineke E Buffart; Nicole C T van Grieken; Marianne Tijssen; Jordy Coffa; Bauke Ylstra; Heike I Grabsch; Cornelis J H van de Velde; Beatriz Carvalho; Gerrit A Meijer Journal: Virchows Arch Date: 2009-08-21 Impact factor: 4.064
Authors: Tineke E Buffart; Beatriz Carvalho; Thomas Mons; Rui M Reis; Cátia Moutinho; Paula Silva; Nicole C T van Grieken; Michael Vieth; Manfred Stolte; Cornelis J H van de Velde; Evelin Schrock; Anja Matthaei; Bauke Ylstra; Fátima Carneiro; Gerrit A Meijer Journal: BMC Genomics Date: 2007-10-01 Impact factor: 3.969