PURPOSE: The purpose of this study was to use a combined x-ray angiography and MR imaging (XMR) system to manipulate intraarterial catheters and monitor the deposition of gadolinium (Gd)-impregnated embolic microspheres in vivo in a canine kidney model. MATERIALS AND METHODS: Seven anesthetized dogs (18-28 kg) were studied. The renal arteries were catheterized under fluoroscopic guidance. Renal blood flow rates were assessed with velocity-encoded cine MR imaging before and after renal artery embolization with Gd-impregnated microspheres (300-500 and 500-700 micro m in size). The particles were injected in vivo into 14 canine renal arteries under fast dynamic T1-weighted MR imaging guidance at one frame per second. Postembolic microsphere distributions were assessed with MR imaging and digital subtraction angiography (DSA). RESULTS: Gd-impregnated microsphere injection into the renal arteries was successful in all animals. Renal enhancement due to the deposition of the particles persisted for at least 1 hour after the injection. The distribution of MR signal enhancement in the kidneys differed for the smaller versus the larger microspheres. The 300-500- micro m microspheres deposited preferentially in the outer cortical regions, whereas the 500-700- micro m microspheres preferentially deposited in the medulla and inner cortex. Renal blood flow was significantly reduced after the administration of both the 300-500- micro m microspheres (from 3.9 to 1.0 mL/min/g) and the 500-700- micro m microspheres (from 3.5 to 0.2 mL/min/g). CONCLUSION: MR imaging permits real-time guidance of arterial embolization with Gd-impregnated microspheres.
PURPOSE: The purpose of this study was to use a combined x-ray angiography and MR imaging (XMR) system to manipulate intraarterial catheters and monitor the deposition of gadolinium (Gd)-impregnated embolic microspheres in vivo in a canine kidney model. MATERIALS AND METHODS: Seven anesthetized dogs (18-28 kg) were studied. The renal arteries were catheterized under fluoroscopic guidance. Renal blood flow rates were assessed with velocity-encoded cine MR imaging before and after renal artery embolization with Gd-impregnated microspheres (300-500 and 500-700 micro m in size). The particles were injected in vivo into 14 canine renal arteries under fast dynamic T1-weighted MR imaging guidance at one frame per second. Postembolic microsphere distributions were assessed with MR imaging and digital subtraction angiography (DSA). RESULTS:Gd-impregnated microsphere injection into the renal arteries was successful in all animals. Renal enhancement due to the deposition of the particles persisted for at least 1 hour after the injection. The distribution of MR signal enhancement in the kidneys differed for the smaller versus the larger microspheres. The 300-500- micro m microspheres deposited preferentially in the outer cortical regions, whereas the 500-700- micro m microspheres preferentially deposited in the medulla and inner cortex. Renal blood flow was significantly reduced after the administration of both the 300-500- micro m microspheres (from 3.9 to 1.0 mL/min/g) and the 500-700- micro m microspheres (from 3.5 to 0.2 mL/min/g). CONCLUSION: MR imaging permits real-time guidance of arterial embolization with Gd-impregnated microspheres.
Authors: Karun V Sharma; Matthew R Dreher; Yiqing Tang; William Pritchard; Oscar A Chiesa; John Karanian; Jennifer Peregoy; Babak Orandi; David Woods; Danielle Donahue; Juan Esparza; Guy Jones; Sean L Willis; Andrew L Lewis; Bradford J Wood Journal: J Vasc Interv Radiol Date: 2010-06 Impact factor: 3.464
Authors: Matthew R Dreher; Karun V Sharma; David L Woods; Goutham Reddy; Yiqing Tang; William F Pritchard; Oscar A Chiesa; John W Karanian; Juan A Esparza; Danielle Donahue; Elliot B Levy; Sean L Willis; Andrew L Lewis; Bradford J Wood Journal: J Vasc Interv Radiol Date: 2011-12-16 Impact factor: 3.464