Literature DB >> 14507176

A new class of branched aminoglycosides: pseudo-pentasaccharide derivatives of neomycin B.

Micha Fridman1, Valery Belakhov, Sima Yaron, Timor Baasov.   

Abstract

[reaction: see text] The clinically important antibiotic neomycin B was modified at position C5' ' by adding one extra sugar ring in the beta-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.

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Year:  2003        PMID： 14507176     DOI： 10.1021/ol035213i

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

1.  6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes.

Authors:  Ido M Herzog; Keith D Green; Yifat Berkov-Zrihen; Mark Feldman; Roee R Vidavski; Anat Eldar-Boock; Ronit Satchi-Fainaro; Avigdor Eldar; Sylvie Garneau-Tsodikova; Micha Fridman
Journal:  Angew Chem Int Ed Engl       Date:  2012-04-12       Impact factor: 15.336

Review 2.  Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Chem Soc Rev       Date:  2018-02-19       Impact factor: 54.564

3.  Antifungal Amphiphilic Aminoglycosides.

Authors:  C-W T Chang; J Y Takemoto
Journal:  Medchemcomm       Date:  2014-08-01       Impact factor: 3.597

4.  Rapid synthesis, RNA binding, and antibacterial screening of a peptidic-aminosugar (PA) library.

Authors:  Liuwei Jiang; Derrick Watkins; Yi Jin; Changjun Gong; Ada King; Arren Z Washington; Keith D Green; Sylvie Garneau-Tsodikova; Adegboyega K Oyelere; Dev P Arya
Journal:  ACS Chem Biol       Date:  2015-02-23       Impact factor: 5.100

5.  Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics.

Authors:  Jonathan C K Quirke; Girish C Sati; Amr Sonousi; Marina Gysin; Klara Haldimann; Erik C Böttger; Andrea Vasella; Sven N Hobbie; David Crich
Journal:  ChemMedChem       Date:  2022-04-22       Impact factor: 3.540

6.  Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila.

Authors:  Desiree H Fong; Christopher T Lemke; Jiyoung Hwang; Bing Xiong; Albert M Berghuis
Journal:  J Biol Chem       Date:  2010-01-19       Impact factor: 5.157

7.  Surprising alteration of antibacterial activity of 5"-modified neomycin against resistant bacteria.

Authors:  Jianjun Zhang; Fang-I Chiang; Long Wu; Przemyslaw Greg Czyryca; Ding Li; Cheng-Wei Tom Chang
Journal:  J Med Chem       Date:  2008-12-11       Impact factor: 7.446

8.  2-Deoxystreptamine Conjugates by Truncation-Derivatization of Neomycin.

Authors:  M Waqar Aslam; Leandro C Tabares; Alessio Andreoni; Gerard W Canters; Floris P J T Rutjes; Floris L Van Delft
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-15

9.  Late-Stage Modification of Aminoglycoside Antibiotics Overcomes Bacterial Resistance Mediated by APH(3') Kinases.

Authors:  Andreas A Bastian; Maria Bastian; Manuel Jäger; Mark Loznik; Eliza M Warszawik; Xintong Yang; Nabil Tahiri; Peter Fodran; Martin D Witte; Anne Thoma; Jens Köhler; Adriaan J Minnaard; Andreas Herrmann
Journal:  Chemistry       Date:  2022-05-17       Impact factor: 5.020
  9 in total

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