AIMS: To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC). METHODS: One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of glutathione S-transferase M1-1 (GSTM1) and T1-1 (GSTT1) were investigated by PCR; occupational history was collected by a structured questionnaire. RESULTS: Subjects with GSTM1 present genotype showed higher risks for RCC, compared to GSTM1 null subjects, if exposed to metals (OR 2.73; 95% CI 0.91 to 8.22 v 1.14; 95% CI 0.46 to 2.82) or pesticides (OR 3.46; 95% CI 1.12 to 10.74 v 1.59; 95% CI 0.48 to 5.34). The GSTT1 present genotype also enhanced the risk (about twofold) of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. CONCLUSIONS: Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
AIMS: To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC). METHODS: One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of glutathione S-transferase M1-1 (GSTM1) and T1-1 (GSTT1) were investigated by PCR; occupational history was collected by a structured questionnaire. RESULTS: Subjects with GSTM1 present genotype showed higher risks for RCC, compared to GSTM1 null subjects, if exposed to metals (OR 2.73; 95% CI 0.91 to 8.22 v 1.14; 95% CI 0.46 to 2.82) or pesticides (OR 3.46; 95% CI 1.12 to 10.74 v 1.59; 95% CI 0.48 to 5.34). The GSTT1 present genotype also enhanced the risk (about twofold) of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. CONCLUSIONS: Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
Authors: S Garte; L Gaspari; A K Alexandrie; C Ambrosone; H Autrup; J L Autrup; H Baranova; L Bathum; S Benhamou; P Boffetta; C Bouchardy; K Breskvar; J Brockmoller; I Cascorbi; M L Clapper; C Coutelle; A Daly; M Dell'Omo; V Dolzan; C M Dresler; A Fryer; A Haugen; D W Hein; A Hildesheim; A Hirvonen; L L Hsieh; M Ingelman-Sundberg; I Kalina; D Kang; M Kihara; C Kiyohara; P Kremers; P Lazarus; L Le Marchand; M C Lechner; E M van Lieshout; S London; J J Manni; C M Maugard; S Morita; V Nazar-Stewart; K Noda; Y Oda; F F Parl; R Pastorelli; I Persson; W H Peters; A Rannug; T Rebbeck; A Risch; L Roelandt; M Romkes; D Ryberg; J Salagovic; B Schoket; J Seidegard; P G Shields; E Sim; D Sinnet; R C Strange; I Stücker; H Sugimura; J To-Figueras; P Vineis; M C Yu; E Taioli Journal: Cancer Epidemiol Biomarkers Prev Date: 2001-12 Impact factor: 4.254
Authors: C Sweeney; D C Farrow; S M Schwartz; D L Eaton; H Checkoway; T L Vaughan Journal: Cancer Epidemiol Biomarkers Prev Date: 2000-04 Impact factor: 4.254
Authors: C Gallou; S Longuemaux; C Deloménie; A Méjean; N Martin; S Martinet; G Palais; R Bouvier; D Droz; R Krishnamoorthy; C Junien; C Béroud; J M Dupret Journal: Pharmacogenetics Date: 2001-08
Authors: A J Meyer; A Hernandez; A R Florl; J Enczmann; C D Gerharz; W A Schulz; P Wernet; R Ackermann Journal: Int J Cancer Date: 2000-09-01 Impact factor: 7.396
Authors: S Karami; P Boffetta; N Rothman; R J Hung; T Stewart; D Zaridze; M Navritalova; D Mates; V Janout; H Kollarova; V Bencko; N Szeszenia-Dabrowska; I Holcatova; A Mukeria; J Gromiec; S J Chanock; P Brennan; W-H Chow; L E Moore Journal: Carcinogenesis Date: 2008-06-19 Impact factor: 4.944
Authors: Tatjana Simic; Ana Savic-Radojevic; Marija Pljesa-Ercegovac; Marija Matic; Jasmina Mimic-Oka Journal: Nat Rev Urol Date: 2009-05 Impact factor: 14.432
Authors: Zorica Reljic; Mario Zlatovic; Ana Savic-Radojevic; Tatjana Pekmezovic; Ljubica Djukanovic; Marija Matic; Marija Pljesa-Ercegovac; Jasmina Mimic-Oka; Dejan Opsenica; Tatjana Simic Journal: Toxins (Basel) Date: 2014-08-08 Impact factor: 4.546
Authors: Marija G Matic; Vesna M Coric; Ana R Savic-Radojevic; Petar V Bulat; Marija S Pljesa-Ercegovac; Dejan P Dragicevic; Tatjana I Djukic; Tatjana P Simic; Tatjana D Pekmezovic Journal: PLoS One Date: 2014-06-10 Impact factor: 3.240
Authors: Vesna M Coric; Tatjana P Simic; Tatjana D Pekmezovic; Gordana M Basta-Jovanovic; Ana R Savic Radojevic; Sanja M Radojevic-Skodric; Marija G Matic; Dejan P Dragicevic; Tanja M Radic; Ljiljana M Bogdanovic; Zoran M Dzamic; Marija S Pljesa-Ercegovac Journal: PLoS One Date: 2016-08-08 Impact factor: 3.240